Document Detail

Loop diuretics and ultrafiltration in heart failure.
MedLine Citation:
PMID:  23795809     Owner:  NLM     Status:  Publisher    
Introduction: Despite widespread use of loop diuretics in congestive heart failure (HF) to achieve decongestion and relief of symptoms, as recommended by the current guidelines, there is uncertainty as to their long-term therapeutic efficacy and safety. Their efficacy and safety compared to venous ultrafiltration are currently under investigation in acute decompensated HF patients. Areas covered: In this article, the authors review current available data related to efficacy and safety of loop diuretics and ultrafiltration in HF. Expert opinion: The literature review highlights an unmet clinical need for evidence-based algorithms, potentially using not only the classical clinical signs and symptoms of congestion as well as the estimated glomerular filtration rate and serum electrolytes, but also biomarkers of congestion/decongestion, neurohumoural activation or urinary kidney injury molecules, in order to optimize both loop diuretics and renin-angiotensin-aldosterone system blocker use in HF patients.
Patrick Rossignol; Faiez Zannad
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-6-25
Journal Detail:
Title:  Expert opinion on pharmacotherapy     Volume:  -     ISSN:  1744-7666     ISO Abbreviation:  Expert Opin Pharmacother     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-6-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100897346     Medline TA:  Expert Opin Pharmacother     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
INSERM, Centre d'Investigations Cliniques, Université de Lorraine and CHU de Nancy , 9501, UMR 1116, Vandoeuvre lès Nancy , France.
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