Document Detail

Longterm treatment of psoriasis using fumaric acid preparations can be associated with severe proximal tubular damage.
MedLine Citation:
PMID:  10627662     Owner:  NLM     Status:  MEDLINE    
Fumaric acid preparations are used as longterm and effective treatment of psoriasis. Apart from gastrointestinal, dermatological and hematological side-effects, transient renal damage was observed during treatment with fumaric acid. The case of a 38 year old woman who was treated with fumaric acid (420 mg bid) for 5 years before she complained of fatigue and weakness. According to clinical laboratory she had developed severe proximal tubular damage. Hypophosphatemia, glycosuria and proteinuria persisted although medication was stopped immediately.
C Raschka; H J Koch
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Human & experimental toxicology     Volume:  18     ISSN:  0960-3271     ISO Abbreviation:  Hum Exp Toxicol     Publication Date:  1999 Dec 
Date Detail:
Created Date:  2000-03-01     Completed Date:  2000-03-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9004560     Medline TA:  Hum Exp Toxicol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  738-9     Citation Subset:  IM    
General Hospital Fulda, Medical Department, Pacelliallee 4, 36043 Fulda, Germany.
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MeSH Terms
Fanconi Syndrome / chemically induced*,  diagnosis*
Fumarates / adverse effects*,  therapeutic use
Glycosuria / chemically induced,  diagnosis
Hypophosphatemia / chemically induced,  diagnosis
Proteinuria / chemically induced,  diagnosis
Psoriasis / drug therapy*
Reg. No./Substance:
0/Fumarates; 110-17-8/fumaric acid

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