Document Detail


Longterm results of auranofin therapy.
MedLine Citation:
PMID:  3690986     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The results of longterm therapy with the oral gold preparation auranofin in patients with rheumatoid arthritis (RA) were evaluated based on the following data: 1) Two multicenter open uncontrolled studies (MTC06) and (162EMUA-RA), 2) the reevaluation of these data for the MTC06 study after 4 years from the beginning of the study and 3) the results of a postmarketing surveillance program (PMSP) of patients on auranofin therapy. The specific rheumatologic documentation and information system (IKR inhaltkodierte rheumatologic) serves as the basis of the follow-up studies and longterm observations. The first year data on 207 patients (MTC06) indicating that duration of the disease less than 2 years was the only discriminating factor regarding a positive treatment outcome were confirmed by the two-year (151 patients). Patients, who responded favourably to Auranofin did usually well for the four-year or longer observation period. The data base of these two studies and the PMSP failed to outline any new severe or threatening side effects. Diarrhea and loose stools were more common at the beginning of the treatment. The overall withdrawal for untoward events was 11.2%. Patients who did or did not respond to previous DIMARD therapy either on i.m. gold, D-Penicillamine or Chloroquine, did usually well when treated with Auranofin, even if severe side effects leading to withdrawal had occurred on previous therapy. The favourable safety profile was confirmed by the PMSP data.
Authors:
K K Bandilla; B Missler
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical rheumatology     Volume:  6 Suppl 2     ISSN:  0770-3198     ISO Abbreviation:  Clin. Rheumatol.     Publication Date:  1987 Sep 
Date Detail:
Created Date:  1988-02-20     Completed Date:  1988-02-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8211469     Medline TA:  Clin Rheumatol     Country:  BELGIUM    
Other Details:
Languages:  eng     Pagination:  35-42     Citation Subset:  IM    
Affiliation:
Deutsche Klinik für Diagnostik, Wiesbaden, FRG.
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MeSH Terms
Descriptor/Qualifier:
Arthritis, Rheumatoid / drug therapy*
Auranofin / adverse effects,  therapeutic use*
Female
Follow-Up Studies
Humans
Male
Middle Aged
Product Surveillance, Postmarketing
Chemical
Reg. No./Substance:
34031-32-8/Auranofin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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