Document Detail

LongoVital in the treatment of Sjögren's syndrome.
MedLine Citation:
PMID:  10544835     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Sjögren's syndrome (SS) is a chronic autoimmune disease complex of unknown aetiology. There is no curative treatment for SS, however, in recent years the influence of nutrients on autoimmune processes has attracted increasing attention. LongoVital (LV) (DK. Reg. No. 5178/75) is an herbal-based tablet enriched with the recommended daily doses of vitamins. The purpose of the present study was to investigate whether 4 months' daily intake of LV as compared to placebo would affect clinical and laboratory disease parameters in patients with SS. METHODS: Forty patients with SS participated in a placebo-controlled, double-blind, randomised, clinical, 8 month cross-over study. Group A (n = 22) received LV during the first 4 months and Group B (n = 18) LV during the last 4 months. RESULTS: The unstimulated salivary flow rate increased during the LV period in Group A (p < 0.001). The stimulated salivary flow rate increased in Group B during the LV period (p < 0.05), and in Group A during the subsequent 4 months on placebo (p < 0.05). The rose bengal score decreased in Group B during (p < 0.01) and in Group A after the LV intake (p < 0.05). During the last 4 months of the study both groups showed an increase in serum levels of alpha-amylase (total: Group A, p < 0.01; Group B, p < 0.05; pancreatic fraction: Group A, p < 0.0001; Group B, p < 0.01) and in serum levels of IgM (Group A and B: p < 0.001), while levels of circulating immune complexes decreased (Group A, p < 0.05; Group B, p < 0.001). CONCLUSION: It is concluded that LV has a beneficial and prolonged effect on some of the clinical and immunoinflammatory disease markers in SS.
A Pedersen; N Gerner; I Palmvang; M Høier-Madsen
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Clinical and experimental rheumatology     Volume:  17     ISSN:  0392-856X     ISO Abbreviation:  Clin. Exp. Rheumatol.     Publication Date:    1999 Sep-Oct
Date Detail:
Created Date:  1999-11-26     Completed Date:  1999-11-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8308521     Medline TA:  Clin Exp Rheumatol     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  533-8     Citation Subset:  IM    
Department of Oral and Maxillofacial Surgery, Bispebjerg Hospital, Copenhagen, Denmark.
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MeSH Terms
Aged, 80 and over
Antibody Formation / drug effects
Antigen-Antibody Complex / blood
Biological Markers
Cross-Over Studies
Double-Blind Method
Immunoglobulin M / blood
Middle Aged
Sjogren's Syndrome / drug therapy*,  immunology
Treatment Outcome
Vitamins / administration & dosage*
Reg. No./Substance:
0/Antigen-Antibody Complex; 0/Biological Markers; 0/Immunoglobulin M; 0/Vitamins

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