Document Detail


LongoVital in the treatment of Sjögren's syndrome.
MedLine Citation:
PMID:  10544835     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Sjögren's syndrome (SS) is a chronic autoimmune disease complex of unknown aetiology. There is no curative treatment for SS, however, in recent years the influence of nutrients on autoimmune processes has attracted increasing attention. LongoVital (LV) (DK. Reg. No. 5178/75) is an herbal-based tablet enriched with the recommended daily doses of vitamins. The purpose of the present study was to investigate whether 4 months' daily intake of LV as compared to placebo would affect clinical and laboratory disease parameters in patients with SS. METHODS: Forty patients with SS participated in a placebo-controlled, double-blind, randomised, clinical, 8 month cross-over study. Group A (n = 22) received LV during the first 4 months and Group B (n = 18) LV during the last 4 months. RESULTS: The unstimulated salivary flow rate increased during the LV period in Group A (p < 0.001). The stimulated salivary flow rate increased in Group B during the LV period (p < 0.05), and in Group A during the subsequent 4 months on placebo (p < 0.05). The rose bengal score decreased in Group B during (p < 0.01) and in Group A after the LV intake (p < 0.05). During the last 4 months of the study both groups showed an increase in serum levels of alpha-amylase (total: Group A, p < 0.01; Group B, p < 0.05; pancreatic fraction: Group A, p < 0.0001; Group B, p < 0.01) and in serum levels of IgM (Group A and B: p < 0.001), while levels of circulating immune complexes decreased (Group A, p < 0.05; Group B, p < 0.001). CONCLUSION: It is concluded that LV has a beneficial and prolonged effect on some of the clinical and immunoinflammatory disease markers in SS.
Authors:
A Pedersen; N Gerner; I Palmvang; M Høier-Madsen
Related Documents :
23154395 - Changes of quality of life in gastric cancer patients after curative resection: a longi...
9204355 - Iopentol (imagopaque 250) compared with diatrizoate (urografin 219) in endoscopic retro...
17403225 - Does the addition of sublingual gland excision to submandibular duct relocation give be...
24596235 - Comparison of long-term quality-of-life outcomes in vestibular schwannoma patients.
23135425 - Chair-side generated posterior lithium disilicate crowns after 4 years.
17943505 - Modified constraint-induced therapy for children with hemiplegic cerebral palsy: a feas...
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Clinical and experimental rheumatology     Volume:  17     ISSN:  0392-856X     ISO Abbreviation:  Clin. Exp. Rheumatol.     Publication Date:    1999 Sep-Oct
Date Detail:
Created Date:  1999-11-26     Completed Date:  1999-11-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8308521     Medline TA:  Clin Exp Rheumatol     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  533-8     Citation Subset:  IM    
Affiliation:
Department of Oral and Maxillofacial Surgery, Bispebjerg Hospital, Copenhagen, Denmark. pedersen-wind@email.dk
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Antibody Formation / drug effects
Antigen-Antibody Complex / blood
Biological Markers
Cross-Over Studies
Double-Blind Method
Female
Humans
Immunoglobulin M / blood
Male
Middle Aged
Phytotherapy*
Sjogren's Syndrome / drug therapy*,  immunology
Treatment Outcome
Vitamins / administration & dosage*
Chemical
Reg. No./Substance:
0/Antigen-Antibody Complex; 0/Biological Markers; 0/Immunoglobulin M; 0/Vitamins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Conventional monotherapy compared to a &quot;sawtooth&quot; treatment strategy in the radiographic p...
Next Document:  Causes of death in Korean patients with systemic lupus erythematosus: a single center retrospective ...