Document Detail


Longitudinal study of various transport abnormalities as an index of severity in children and adolescents suffering from essential hypertension.
MedLine Citation:
PMID:  2168456     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Erythrocyte cation fluxes were measured in fresh cells, on two different occasions, in 90 children and adolescents suffering from essential hypertension who were followed for a prolonged period. The purpose of the present study was to track the stability of erythrocyte cation fluxes with time, and to determine whether a known sodium transport abnormality can predict the severity of essential hypertension. The patients with an increased Na-Li countertransport were the most severely hypertensive in three different ways. Clinically, they presented a stable rather than a labile form of hypertension. Hemodynamically, the mean arterial pressure was higher than that of the other subgroups. Finally, in those children followed for more than 2 years, this subgroup remained hypertensive with time. The patients with a decreased Na,K cotransport activity were second in severity; however, blood pressure was often labile, mean arterial pressure was slightly lower than that of the previous subgroup and all patients remained hypertensive with time but in four out of six patients the hypertension was labile. The patients with increased passive sodium permeability presented a mild form of hypertension. The patients with normal erythrocyte cation fluxes seemed to form a heterogeneous group. A few were severely hypertensive, but in most the hypertension was borderline and transient. We conclude that determination of erythrocyte cation fluxes may be reproducible, and may be a useful index of the severity of essential hypertension in children and adolescents.
Authors:
J G Mongeau; P Mauran; G Poirot; A Davignon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of hypertension     Volume:  8     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  1990 Jul 
Date Detail:
Created Date:  1990-10-05     Completed Date:  1990-10-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  657-62     Citation Subset:  IM    
Affiliation:
Service of Nephrology and Cardiology, Ste Justine Hospital, Montreal, Canada.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Antiporters*
Biological Transport, Active
Carrier Proteins / blood
Child
Erythrocytes / metabolism
Female
Humans
Hypertension / blood*,  epidemiology
Longitudinal Studies
Male
Sodium / pharmacokinetics*
Sodium-Potassium-Chloride Symporters
Chemical
Reg. No./Substance:
0/Antiporters; 0/Carrier Proteins; 0/Sodium-Potassium-Chloride Symporters; 0/sodium-lithium countertransporter; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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