| Longitudinal study of plasma pregnenolone and 17-hydroxypregnenolone in full-term and preterm neonates at birth and during the early neonatal period. | |
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MedLine Citation:
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PMID: 12213889 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pregnenolone (Preg) and 17-hydroxypregnenolone (17OH-Preg) are marker steroids that are elevated in the 3beta-hydroxysteroid-dehydrogenase-II deficiency form of congenital adrenal hyperplasia. The aim of this study was to establish normative data for both steroids in healthy preterm (28-33 and 34-37 wk gestation) and full-term infants, because reference values for the early neonatal period do not exist. At delivery, the main source of Preg is the placenta, because the highest levels were found in the retroplacental space (median, 141.31 nmol/liter), with no significant difference between preterm and full-term pregnancies. The fetal adrenals provide most of the circulating 17OH-Preg in full-term neonates, as demonstrated by a marked arteriovenous gradient in cord blood (40.96 nmol/liter vs. 10.77 nmol/liter). 17OH-Preg levels in the umbilical arteries were significantly lower in premature infants than in full-term infants (8.06 nmol/liter vs. 40.96 nmol/liter). During the first 2 postnatal weeks, Preg concentrations showed a rapid and significant fall in early preterm infants [95.78 nmol/liter (0 h) to 36.69 nmol/liter (d 14)] as well as in full-term infants [66.62 nmol/liter (0 h) to 14.81 nmol/liter (d 6)]. In addition, a significant fall in 17OH-Preg levels was found in full-term neonates [40.96 nmol/liter (0 h) to 11.32 nmol/liter (d 6)]. After 12 h, significantly higher levels for Preg and 17OH-Preg were found in early preterm infants (98.01 nmol/liter and 69.13 nmol/liter), compared with full-term neonates (36.29 nmol/liter and 28.55 nmol/liter, P < 0.05), reflecting the increased fetocortical activity as a response to the stress of delivery in the prematures. With these longitudinal data, it is now possible to confirm or exclude the diagnosis of 3beta-hydroxysteroid-dehydrogenase-II deficiency within the first postnatal week. |
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Authors:
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Felix G Riepe; Philip Mahler; Wolfgang G Sippell; Carl-Joachim Partsch |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: 87 ISSN: 0021-972X ISO Abbreviation: J. Clin. Endocrinol. Metab. Publication Date: 2002 Sep |
Date Detail:
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Created Date: 2002-09-05 Completed Date: 2002-10-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: United States |
Other Details:
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Languages: eng Pagination: 4301-6 Citation Subset: AIM; IM |
Affiliation:
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Division of Paediatric Endocrinology, Department of Paediatrics, Christian-Albrechts-University Kiel, 24105 Kiel, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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17-alpha-Hydroxypregnenolone
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blood* Aging / physiology* Birth Weight Female Gestational Age Humans Infant, Newborn / blood*, growth & development, physiology Infant, Premature / blood*, growth & development, physiology Longitudinal Studies Male Maternal-Fetal Exchange Pregnancy Pregnenolone / blood* Reference Values Time Factors |
| Chemical | |
Reg. No./Substance:
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145-13-1/Pregnenolone; 387-79-1/17-alpha-Hydroxypregnenolone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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