Document Detail


Longitudinal study of plasma pregnenolone and 17-hydroxypregnenolone in full-term and preterm neonates at birth and during the early neonatal period.
MedLine Citation:
PMID:  12213889     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pregnenolone (Preg) and 17-hydroxypregnenolone (17OH-Preg) are marker steroids that are elevated in the 3beta-hydroxysteroid-dehydrogenase-II deficiency form of congenital adrenal hyperplasia. The aim of this study was to establish normative data for both steroids in healthy preterm (28-33 and 34-37 wk gestation) and full-term infants, because reference values for the early neonatal period do not exist. At delivery, the main source of Preg is the placenta, because the highest levels were found in the retroplacental space (median, 141.31 nmol/liter), with no significant difference between preterm and full-term pregnancies. The fetal adrenals provide most of the circulating 17OH-Preg in full-term neonates, as demonstrated by a marked arteriovenous gradient in cord blood (40.96 nmol/liter vs. 10.77 nmol/liter). 17OH-Preg levels in the umbilical arteries were significantly lower in premature infants than in full-term infants (8.06 nmol/liter vs. 40.96 nmol/liter). During the first 2 postnatal weeks, Preg concentrations showed a rapid and significant fall in early preterm infants [95.78 nmol/liter (0 h) to 36.69 nmol/liter (d 14)] as well as in full-term infants [66.62 nmol/liter (0 h) to 14.81 nmol/liter (d 6)]. In addition, a significant fall in 17OH-Preg levels was found in full-term neonates [40.96 nmol/liter (0 h) to 11.32 nmol/liter (d 6)]. After 12 h, significantly higher levels for Preg and 17OH-Preg were found in early preterm infants (98.01 nmol/liter and 69.13 nmol/liter), compared with full-term neonates (36.29 nmol/liter and 28.55 nmol/liter, P < 0.05), reflecting the increased fetocortical activity as a response to the stress of delivery in the prematures. With these longitudinal data, it is now possible to confirm or exclude the diagnosis of 3beta-hydroxysteroid-dehydrogenase-II deficiency within the first postnatal week.
Authors:
Felix G Riepe; Philip Mahler; Wolfgang G Sippell; Carl-Joachim Partsch
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  87     ISSN:  0021-972X     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  2002 Sep 
Date Detail:
Created Date:  2002-09-05     Completed Date:  2002-10-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4301-6     Citation Subset:  AIM; IM    
Affiliation:
Division of Paediatric Endocrinology, Department of Paediatrics, Christian-Albrechts-University Kiel, 24105 Kiel, Germany.
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MeSH Terms
Descriptor/Qualifier:
17-alpha-Hydroxypregnenolone / blood*
Aging / physiology*
Birth Weight
Female
Gestational Age
Humans
Infant, Newborn / blood*,  growth & development,  physiology
Infant, Premature / blood*,  growth & development,  physiology
Longitudinal Studies
Male
Maternal-Fetal Exchange
Pregnancy
Pregnenolone / blood*
Reference Values
Time Factors
Chemical
Reg. No./Substance:
145-13-1/Pregnenolone; 387-79-1/17-alpha-Hydroxypregnenolone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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