Document Detail

Longitudinal study of fetal middle cerebral artery flow velocity waveforms preceding fetal death.
MedLine Citation:
PMID:  8534624     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess longitudinally fetal cerebral vasodilatation in small-for-gestational age fetuses to investigate whether intrauterine death might be predictable. DESIGN: Prospective observational study. SETTING: Ultrasound department in a university hospital. SUBJECTS: Five pregnancies with ultrasonographically confirmed small fetuses (abdominal circumference less than the 3rd centile) monitored longitudinally until time of intrauterine death. MAIN OUTCOME MEASURE: Time between last ultrasound examination and diagnosis of intrauterine death, and variation in middle cerebral artery pulsitility index prior to death. RESULTS: Two of the five fetuses showed a reversal of adaptation (as indicated by an elevation of the middle cerebral artery pulsitility index) within 48 hours of intrauterine death. The other three had their final ultrasound examination 3 to 7 days before death and showed no such reversal of adaptation. CONCLUSION: Reversal of adaptation in fetal hypoxaemia as indicated by a rise in the middle cerebral artery pulsitility index may be a predictor of intrauterine death within 48 hours. Whether delivery after reversal of adaptation would result in salvage of neurologically intact babies needs to be investigated.
D J Rowlands; S K Vyas
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of obstetrics and gynaecology     Volume:  102     ISSN:  0306-5456     ISO Abbreviation:  Br J Obstet Gynaecol     Publication Date:  1995 Nov 
Date Detail:
Created Date:  1996-02-06     Completed Date:  1996-02-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7503752     Medline TA:  Br J Obstet Gynaecol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  888-90     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynaecology, Derriford Hospital, Plymouth, UK.
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MeSH Terms
Blood Flow Velocity
Cerebral Arteries / physiopathology*
Fetal Death / physiopathology*,  prevention & control
Fetal Growth Retardation / physiopathology
Longitudinal Studies
Prospective Studies
Ultrasonography, Prenatal
Comment In:
Br J Obstet Gynaecol. 1996 Aug;103(8):852   [PMID:  8760724 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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