Document Detail

Longitudinal study of cerebrospinal fluid amyloid proteins and apolipoprotein E in patients with probable Alzheimer's disease.
MedLine Citation:
PMID:  9672379     Owner:  NLM     Status:  MEDLINE    
Levels of soluble amyloid beta protein (sAbeta), amyloid beta precursor protein (APP) and apolipoprotein E (apoE) were examined in cerebrospinal fluid (CSF) obtained twice, at baseline and after 3-year follow-up, from 25 patients with probable Alzheimer's disease (AD). Levels of sAbeta and apoE from patients with the apoE4 allele decreased with time, whereas the levels were similar in patients without apoE4 allele. Changes of sAbeta and apoE concentrations correlated significantly with those of mini-mental state examination (MMSE) scores. Levels of sAbeta did not change with time in patients with mild dementia, whereas they decreased significantly in patients with moderate dementia. ApoE concentrations decreased in both groups whereas APP levels were similar. We conclude that measurements of CSF sAbeta and apoE levels may be helpful in monitoring progression of the disease.
T Pirttilä; K Koivisto; P D Mehta; K Reinikainen; K S Kim; O Kilkku; E Heinonen; H Soininen; P Riekkinen; H M Wisniewski
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neuroscience letters     Volume:  249     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  1998 Jun 
Date Detail:
Created Date:  1998-09-03     Completed Date:  1998-09-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  21-4     Citation Subset:  IM    
Department of Neurology, Kuopio University Hospital and University of Kuopio, Finland.
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MeSH Terms
Alzheimer Disease / cerebrospinal fluid*,  genetics,  pathology
Amyloid beta-Protein / cerebrospinal fluid*
Amyloid beta-Protein Precursor / cerebrospinal fluid*,  genetics
Apolipoproteins E / cerebrospinal fluid*
Longitudinal Studies
Mental Status Schedule
Reg. No./Substance:
0/Amyloid beta-Protein; 0/Amyloid beta-Protein Precursor; 0/Apolipoproteins E

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