| Longitudinal study of carbon monoxide intoxication by diffusion tensor imaging with neuropsychiatric correlation. | |
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MedLine Citation:
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PMID: 20184809 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: White matter damage is common after carbon monoxide (CO) intoxication, but in vivo follow-up studies about the mechanism of white matter damage are not possible in pathology series. Diffusion tensor imaging (DTI) and voxel-based morphometry (VBM) can quantify diffusion parameters and volumetric changes in white matter that can be correlated with neuropsychological performances in longitudinal studies. METHODS: We examined 9 patients with CO intoxication using DTI, VBM and neuropsychologic tests at an average of 3 and 10 months after CO exposure. We used data from 18 age- and sex-matched controls for comparison. RESULTS: We found that cognitive recovery at 10 months after CO intoxication was not significant, although it was after 3 months. The neuropsychologic tests correlated better for the fibre tract of the semicentrum ovale and not the periventricular fibres. Diffusion measures suggest increases in fractional anisotropy, mean diffusivity and axial eigenvalues over time, while increases in radial eigenvalue were evident at 3 months compared with controls. Periventricular white matter atrophy was observed 10 months after CO intoxication. LIMITATIONS: Our study included few cases, and the interpretation of the putative changes on neuroimaging findings cannot be confirmed by histology. CONCLUSION: Our study showed that the evolution of white matter injury in CO encephalopathy occurred over time. Cognitive recovery was not evident in the follow-up period because of white matter injuries. |
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Authors:
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Chiung-Chih Chang; Wen-Neng Chang; Chun-Chung Lui; Jiun-Jie Wang; Chih-Feng Chen; Yu-Chang Lee; Shun-Sheng Chen; Yu-Ting Lin; Chi-Wei Huang; Ching Chen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of psychiatry & neuroscience : JPN Volume: 35 ISSN: 1488-2434 ISO Abbreviation: J Psychiatry Neurosci Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-02-26 Completed Date: 2010-06-02 Revised Date: 2010-09-30 |
Medline Journal Info:
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Nlm Unique ID: 9107859 Medline TA: J Psychiatry Neurosci Country: Canada |
Other Details:
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Languages: eng Pagination: 115-25 Citation Subset: IM |
Affiliation:
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Department of Neurology, Chang Gung Memorial Hospital, Kaohsiung Medical Center and Chang Gung University College of Medicine, Kaohsiung, Taiwan. neur099@adm.cgmh.org.tw |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anisotropy Brain / pathology* Carbon Monoxide Poisoning / complications, pathology* Cognition Cognition Disorders / etiology, pathology* Diffusion Tensor Imaging Female Follow-Up Studies Humans Image Processing, Computer-Assisted Longitudinal Studies Male Middle Aged Nerve Fibers, Myelinated / pathology Neuropsychological Tests Time Factors Young Adult |
| Comments/Corrections | |
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