Document Detail

Longitudinal study of auditory brainstem response in leigh syndrome.
MedLine Citation:
PMID:  12776229     Owner:  NLM     Status:  MEDLINE    
To assess the utility of auditory brainstem response (ABR) in diagnosing brainstem changes in patients with Leigh syndrome (LS), we performed a longitudinal study of five patients with LS using both ABR and neuroimaging techniques (CT and MRI). The brainstem components of the initial ABRs we performed on the patients were abnormal in all five patients. In four of the patients, these abnormal findings preceded any clinical signs of brainstem impairment. Improvements in clinical findings were reflected in improvements in ABR findings in three patients. In one of these three patients, improvements in clinical findings were also reflected in improvements in MRI findings. In the other two patients, MRI findings showed no improvements, despite the improvements in clinical findings. In two of our patients, ABR clearly revealed functional improvements in the brainstem which were not revealed by MRI. Therefore, we conclude that ABR is an essential diagnostic technique for patients with LS.
H Yoshinaga; T Ogino; F Endo; S Yasuhara; N Murakami; Y Ohtsuka; E Oka
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Publication Detail:
Type:  Case Reports; Comparative Study; Evaluation Studies; Journal Article    
Journal Detail:
Title:  Neuropediatrics     Volume:  34     ISSN:  0174-304X     ISO Abbreviation:  Neuropediatrics     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-05-30     Completed Date:  2003-07-09     Revised Date:  2008-01-16    
Medline Journal Info:
Nlm Unique ID:  8101187     Medline TA:  Neuropediatrics     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  81-6     Citation Subset:  IM    
Department of Child Neurology, Okayama University Medical School. Okayama, Japan.
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MeSH Terms
Brain Diseases / diagnosis,  etiology*,  physiopathology*
Brain Stem / pathology*,  physiopathology*,  radiography
Child, Preschool
Evoked Potentials, Auditory, Brain Stem / physiology*
Leigh Disease / complications*,  diagnosis,  physiopathology*
Longitudinal Studies
Magnetic Resonance Imaging
Reproducibility of Results
Tomography, X-Ray Computed

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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