Document Detail


Longitudinal study of [D10]phenanthrene metabolism by the diol epoxide pathway in smokers.
MedLine Citation:
PMID:  23336104     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The extent of metabolism of [D10]phenanthrene to [D(10)]r-1,t-2,3,c-4-tetrahydroxy-1,2,3,4-tetradeuterophenanthrene ([D10]PheT) could be a biomarker of human metabolic activation of carcinogenic polycyclic aromatic hydrocarbons, leading to identification of smokers particularly susceptible to lung cancer. The longitudinal stability of [D10]PheT was evaluated in 24 cigaret smokers given 7-8 oral doses of [D10]phenanthrene (10 µg) over 5.5 months. [D10]PheT in 6 h urine was quantified after each dose. The overall coefficient of variation for 24 subjects was (mean ± S.D.) 27.4% ± 8.83%. Thus, a single administration of [D10]phenanthrene is likely sufficient to determine a smoker's ability to metabolize it to [D10]PheT.
Authors:
Stephen S Hecht; J Bradley Hochalter; Steven G Carmella; Yan Zhang; Diane M Rauch; Naomi Fujioka; Joni Jensen; Dorothy K Hatsukami
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2013-01-22
Journal Detail:
Title:  Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals     Volume:  18     ISSN:  1366-5804     ISO Abbreviation:  Biomarkers     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-15     Completed Date:  2013-07-22     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  9606000     Medline TA:  Biomarkers     Country:  England    
Other Details:
Languages:  eng     Pagination:  144-50     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Adult
Biological Markers / urine
Biotransformation
Carcinogens / metabolism*,  pharmacokinetics
Disease Susceptibility
Female
Gas Chromatography-Mass Spectrometry
Humans
Longitudinal Studies
Lung Neoplasms / etiology,  prevention & control*,  urine
Male
Middle Aged
Phenanthrenes / administration & dosage,  pharmacokinetics,  urine*
Smoking / adverse effects
Grant Support
ID/Acronym/Agency:
CA-77498/CA/NCI NIH HHS; CA-92025/CA/NCI NIH HHS; R01 CA092025/CA/NCI NIH HHS; T32 HL007062/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Carcinogens; 0/Phenanthrenes; 0/r-1,t-2,3,c-4-tetrahydroxy-1,2,3,4-tetrahydrophenanthrene; 448J8E5BST/phenanthrene
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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