| Longitudinal study of [D(10)]phenanthrene metabolism by the diol epoxide pathway in smokers. | |
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MedLine Citation:
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PMID: 23336104 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Abstract The extent of metabolism of [D(10)]phenanthrene to [D(10)]r-1,t-2,3,c-4-tetrahydroxy-1,2,3,4-tetradeuterophenanthrene ([D(10)]PheT) could be a biomarker of human metabolic activation of carcinogenic polycyclic aromatic hydrocarbons, leading to identification of smokers particularly susceptible to lung cancer. The longitudinal stability of [D(10)]PheT was evaluated in 24 cigaret smokers given 7-8 oral doses of [D(10)]phenanthrene (10 µg) over 5.5 months. [D(10)]PheT in 6 h urine was quantified after each dose. The overall coefficient of variation for 24 subjects was (mean ± S.D.) 27.4% ± 8.83%. Thus, a single administration of [D(10)]phenanthrene is likely sufficient to determine a smoker's ability to metabolize it to [D(10)]PheT. |
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Authors:
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Stephen S Hecht; J Bradley Hochalter; Steven G Carmella; Yan Zhang; Diane M Rauch; Naomi Fujioka; Joni Jensen; Dorothy K Hatsukami |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-22 |
Journal Detail:
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Title: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals Volume: - ISSN: 1366-5804 ISO Abbreviation: Biomarkers Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9606000 Medline TA: Biomarkers Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Masonic Cancer Center, University of Minnesota , Minneapolis, MN , USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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