Document Detail


Longitudinal study of Cystatin C in healthy term newborns.
MedLine Citation:
PMID:  21484036     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The purpose of this study was to determine the levels of Cystatin C in healthy term newborns in the first month of life.
INTRODUCTION: Cystatin C may be a suitable marker for determining the glomerular filtration rate because it is not affected by maternal renal function.
METHODS: Cohort study. Inclusion: term newborns with appropriate weight; mother without renal failure or drugs that could affect fetal glomerular filtration rate. Exclusion: malformations; hypertension or any condition that could affect glomerular filtration rate. Cystatin C (mg/L)and creatinine (rng/dl) were determined in the mother (Mo) and in the newborn at birth (Day-0), 3rd (Day-3), 7th(Day-7) and 28t>h(Day-28) days.
STATISTICS: one way ANOVA and Pearson's correlation tests. Sample size of 20 subjects for a = 5% and a power test = 80% (p<0.05).
RESULTS: Data from 21 newborns were obtained (mean + standard deviation): MoCystatin C=1.00 ± 0.20; Day-0 Cystatin C 1.70 ± 0.26; Day-3 Cystatin C = 1.51 ± 0.20; Day-7 Cystatin C = 1.54 ± 0.10; Day-28 Cystatin C = 1.51 ± 0.10. MoCystatin C was smaller than Day-0 Cystatin C (p < 0.001), while MoCreatinine was not different from Day-0 Creatinine. Cystatin C only decreased from Day-0 to Day-3 (p = 0.004) but newborns Creatinine decreased along the time. Correlations were obtained between MoCystatin C and MoCreatinine (p = 0.012), as well as Day-3 (p = 0.047) and Day-28 (p = 0.022) Cystatin C and Creatinine values.
CONCLUSION: Neonatal Cystatin C values were not affected by MoCystatin C and became stable from the 3rd day of life.
Authors:
Ana Carolina de Albuquerque Cavalcanti Ferreira Novo; Lilian Dos Santos Rodrigues Sadeck; Thelma Suely Okay; Clea Rodrigues Leone
Related Documents :
8317656 - Deaths associated with dentistry and dental disease 1980-1989.
9240516 - Deaths related to iodinated contrast media reported spontaneously to the u.s. food and ...
24838096 - Safe oxygen saturation targeting and monitoring in preterm infants. can we avoid hypoxi...
21133966 - Does in utero exposure to synthetic glucocorticoids influence birthweight, head circumf...
1407896 - Clinical evaluation of the nbd-pc fluorescence polarization assay for prediction of fet...
24121146 - Safety and efficacy of delayed release rabeprazole in 1 to 11 month-old infants with sy...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinics (São Paulo, Brazil)     Volume:  66     ISSN:  1980-5322     ISO Abbreviation:  Clinics (Sao Paulo)     Publication Date:  2011  
Date Detail:
Created Date:  2011-04-12     Completed Date:  2011-11-09     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  101244734     Medline TA:  Clinics (Sao Paulo)     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  217-20     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Biological Markers / blood
Creatinine / blood
Cystatin C / blood*
Epidemiologic Methods
Female
Glomerular Filtration Rate / physiology*
Humans
Infant, Newborn
Male
Mothers / statistics & numerical data
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Cystatin C; AYI8EX34EU/Creatinine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effectiveness and safety of outpatient pleurodesis in patients with recurrent malignant pleural effu...
Next Document:  Post-resistance exercise hypotension in patients with intermittent claudication.