Document Detail

Longitudinal study of Cystatin C in healthy term newborns.
MedLine Citation:
PMID:  21484036     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The purpose of this study was to determine the levels of Cystatin C in healthy term newborns in the first month of life.
INTRODUCTION: Cystatin C may be a suitable marker for determining the glomerular filtration rate because it is not affected by maternal renal function.
METHODS: Cohort study. Inclusion: term newborns with appropriate weight; mother without renal failure or drugs that could affect fetal glomerular filtration rate. Exclusion: malformations; hypertension or any condition that could affect glomerular filtration rate. Cystatin C (mg/L)and creatinine (rng/dl) were determined in the mother (Mo) and in the newborn at birth (Day-0), 3rd (Day-3), 7th(Day-7) and 28t>h(Day-28) days.
STATISTICS: one way ANOVA and Pearson's correlation tests. Sample size of 20 subjects for a = 5% and a power test = 80% (p<0.05).
RESULTS: Data from 21 newborns were obtained (mean + standard deviation): MoCystatin C=1.00 ± 0.20; Day-0 Cystatin C 1.70 ± 0.26; Day-3 Cystatin C = 1.51 ± 0.20; Day-7 Cystatin C = 1.54 ± 0.10; Day-28 Cystatin C = 1.51 ± 0.10. MoCystatin C was smaller than Day-0 Cystatin C (p < 0.001), while MoCreatinine was not different from Day-0 Creatinine. Cystatin C only decreased from Day-0 to Day-3 (p = 0.004) but newborns Creatinine decreased along the time. Correlations were obtained between MoCystatin C and MoCreatinine (p = 0.012), as well as Day-3 (p = 0.047) and Day-28 (p = 0.022) Cystatin C and Creatinine values.
CONCLUSION: Neonatal Cystatin C values were not affected by MoCystatin C and became stable from the 3rd day of life.
Ana Carolina de Albuquerque Cavalcanti Ferreira Novo; Lilian Dos Santos Rodrigues Sadeck; Thelma Suely Okay; Clea Rodrigues Leone
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinics (São Paulo, Brazil)     Volume:  66     ISSN:  1980-5322     ISO Abbreviation:  Clinics (Sao Paulo)     Publication Date:  2011  
Date Detail:
Created Date:  2011-04-12     Completed Date:  2011-11-09     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  101244734     Medline TA:  Clinics (Sao Paulo)     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  217-20     Citation Subset:  IM    
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MeSH Terms
Biological Markers / blood
Creatinine / blood
Cystatin C / blood*
Epidemiologic Methods
Glomerular Filtration Rate / physiology*
Infant, Newborn
Mothers / statistics & numerical data
Reg. No./Substance:
0/Biological Markers; 0/Cystatin C; AYI8EX34EU/Creatinine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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