Document Detail

Longitudinal relations between obesity and hypertension following pediatric renal transplantation.
MedLine Citation:
PMID:  20567855     Owner:  NLM     Status:  MEDLINE    
Obesity and hypertension frequently complicate renal transplantation (RTxp). The objective was to assess relations among obesity, hypertension, and glucocorticoids in pediatric RTxp recipients. A retrospective cohort study was carried out in 141 RTxp recipients, 2-21 years of age, with >or=12 months of follow-up. Body mass index Z-score (BMI-Z), systolic and diastolic blood pressure Z-scores (SBP-Z and DBP-Z), and medications at 1, 3, 6, and 12 months and annually thereafter were recorded. Quasi-least squares regression analysis was used. The prevalence of obesity (BMI>or=95th percentile) increased from 13% at baseline to >30% from 3 months onward. Greater glucocorticoid exposure (mg/kg/day) was associated with greater increases in BMI-Z (p<0.001). This association was greater in males, younger recipients, and those with lower baseline BMI-Z (all interactions p<0.02). The prevalence of systolic hypertension (SBP>or=95th percentile) was 73% at 1 month and >or=40% at all follow-up visits. Greater glucocorticoid exposure (p<0.001) and increases in BMI-Z (p=0.005) were independent determinants of SBP-Z over time. Cyclosporine (versus tacrolimus) was independently associated with greater SBP-Z and DBP-Z (p=0.001). Sustained obesity and hypertension frequently complicated pediatric RTxp. Obesity was an independent determinant of systolic hypertension. Strategies are needed to prevent obesity and its impact on hypertension, cardiovascular disease, and allograft survival.
Michelle R Denburg; Madhura Pradhan; Justine Shults; Abigail Jones; Jo Ann Palmer; H Jorge Baluarte; Mary B Leonard
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Publication Detail:
Type:  Journal Article     Date:  2010-06-22
Journal Detail:
Title:  Pediatric nephrology (Berlin, Germany)     Volume:  25     ISSN:  1432-198X     ISO Abbreviation:  Pediatr. Nephrol.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-08-19     Completed Date:  2010-12-02     Revised Date:  2014-06-12    
Medline Journal Info:
Nlm Unique ID:  8708728     Medline TA:  Pediatr Nephrol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  2129-39     Citation Subset:  IM    
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MeSH Terms
Age Factors
Body Mass Index
Child, Preschool
Cohort Studies
Hypertension / epidemiology*,  etiology
Kidney Transplantation / adverse effects*
Longitudinal Studies
Obesity / epidemiology*,  etiology
Retrospective Studies
Risk Factors
Sex Factors
Young Adult
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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