Document Detail


Longitudinal relations between obesity and hypertension following pediatric renal transplantation.
MedLine Citation:
PMID:  20567855     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Obesity and hypertension frequently complicate renal transplantation (RTxp). The objective was to assess relations among obesity, hypertension, and glucocorticoids in pediatric RTxp recipients. A retrospective cohort study was carried out in 141 RTxp recipients, 2-21 years of age, with >or=12 months of follow-up. Body mass index Z-score (BMI-Z), systolic and diastolic blood pressure Z-scores (SBP-Z and DBP-Z), and medications at 1, 3, 6, and 12 months and annually thereafter were recorded. Quasi-least squares regression analysis was used. The prevalence of obesity (BMI>or=95th percentile) increased from 13% at baseline to >30% from 3 months onward. Greater glucocorticoid exposure (mg/kg/day) was associated with greater increases in BMI-Z (p<0.001). This association was greater in males, younger recipients, and those with lower baseline BMI-Z (all interactions p<0.02). The prevalence of systolic hypertension (SBP>or=95th percentile) was 73% at 1 month and >or=40% at all follow-up visits. Greater glucocorticoid exposure (p<0.001) and increases in BMI-Z (p=0.005) were independent determinants of SBP-Z over time. Cyclosporine (versus tacrolimus) was independently associated with greater SBP-Z and DBP-Z (p=0.001). Sustained obesity and hypertension frequently complicated pediatric RTxp. Obesity was an independent determinant of systolic hypertension. Strategies are needed to prevent obesity and its impact on hypertension, cardiovascular disease, and allograft survival.
Authors:
Michelle R Denburg; Madhura Pradhan; Justine Shults; Abigail Jones; Jo Ann Palmer; H Jorge Baluarte; Mary B Leonard
Related Documents :
2286085 - Factors determining arterial blood pressure in childhood.
10842655 - Mechanisms of hypertension and kidney disease in obesity.
18313335 - Obesity and impaired venous function.
18541585 - Ethnic differences in dairy and related nutrient consumption among us adults and their ...
7733365 - Differential hemodynamic effects of l-nmma in endotoxemic and normal dogs.
15979445 - B-type natriuretic peptide and tissue doppler study findings in elderly patients hospit...
Publication Detail:
Type:  Journal Article     Date:  2010-06-22
Journal Detail:
Title:  Pediatric nephrology (Berlin, Germany)     Volume:  25     ISSN:  1432-198X     ISO Abbreviation:  Pediatr. Nephrol.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-08-19     Completed Date:  2010-12-02     Revised Date:  2014-06-12    
Medline Journal Info:
Nlm Unique ID:  8708728     Medline TA:  Pediatr Nephrol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  2129-39     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Age Factors
Body Mass Index
Child
Child, Preschool
Cohort Studies
Female
Humans
Hypertension / epidemiology*,  etiology
Kidney Transplantation / adverse effects*
Longitudinal Studies
Male
Obesity / epidemiology*,  etiology
Prevalence
Retrospective Studies
Risk Factors
Sex Factors
Young Adult
Grant Support
ID/Acronym/Agency:
L40 DK084729/DK/NIDDK NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Vitamin D deficiency and toxicity in chronic kidney disease: in search of the therapeutic window.
Next Document:  How preferences for public participation are linked to perceptions of the context, preferences for o...