Document Detail

Longitudinal postnatal weight measurements for the prediction of retinopathy of prematurity.
MedLine Citation:
PMID:  20385939     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To validate longitudinal postnatal weight gain as a method for predicting severe retinopathy of prematurity (ROP) in a US cohort.
METHODS: Both ROP evaluations and weekly weight measurements from birth to postmenstrual week 36 for 318 infants were entered into a computer-based surveillance system, WINROP. This system signaled an alarm when the rate of weight gain decreased compared with control subjects. Infants were classified into 3 groups: (1) no alarm, (2) low-risk alarm, or (3) high-risk alarm. Maximum ROP for each infant was categorized as (1) no ROP (immature or mature vascularization), (2) mild ROP (stage 1 or 2 ROP in zone II or III, without plus disease), or (3) severe ROP (any prethreshold, any stage 3, or threshold ROP). A high-risk alarm identified infants at risk for developing severe ROP.
RESULTS: A high-risk alarm occurred in 81 infants (25.5%) and detected all infants who developed severe ROP a median of 9 weeks before diagnosis. The remaining infants received no alarm or a low-risk alarm. None of these infants developed more than mild ROP.
CONCLUSIONS: Longitudinal postnatal weight gain may help predict ROP. In a US cohort, the WINROP system had a sensitivity of 100% and identified infants early who developed severe ROP. With further validation, WINROP has the potential to safely reduce the number of ROP examinations.
Carolyn Wu; Deborah K Vanderveen; Ann Hellström; Chatarina Löfqvist; Lois E H Smith
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Publication Detail:
Type:  Journal Article; Validation Studies    
Journal Detail:
Title:  Archives of ophthalmology     Volume:  128     ISSN:  1538-3601     ISO Abbreviation:  Arch. Ophthalmol.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-13     Completed Date:  2010-05-03     Revised Date:  2014-04-28    
Medline Journal Info:
Nlm Unique ID:  7706534     Medline TA:  Arch Ophthalmol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  443-7     Citation Subset:  AIM; IM    
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MeSH Terms
Birth Weight / physiology*
Gestational Age
Infant, Newborn
Infant, Premature
Infant, Very Low Birth Weight
Insulin-Like Growth Factor I / analysis
Longitudinal Studies
Retinopathy of Prematurity / blood,  diagnosis*
Retrospective Studies
Sentinel Surveillance
Weight Gain / physiology*
Reg. No./Substance:
67763-96-6/Insulin-Like Growth Factor I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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