Document Detail


Longitudinal performance of a surgically implanted neuroprosthesis for lower-extremity exercise, standing, and transfers after spinal cord injury.
MedLine Citation:
PMID:  22541312     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To investigate the longitudinal performance of a surgically implanted neuroprosthesis for lower-extremity exercise, standing, and transfers after spinal cord injury.
DESIGN: Case series.
SETTING: Research or outpatient physical therapy departments of 4 academic hospitals.
PARTICIPANTS: Subjects (N=15) with thoracic or low cervical level spinal cord injuries who had received the 8-channel neuroprosthesis for exercise and standing.
INTERVENTION: After completing rehabilitation with the device, the subjects were discharged to unrestricted home use of the system. A series of assessments were performed before discharge and at a follow-up appointment approximately 1 year later.
MAIN OUTCOME MEASURES: Neuroprosthesis usage, maximum standing time, body weight support, knee strength, knee fatigue index, electrode stability, and component survivability.
RESULTS: Levels of maximum standing time, body weight support, knee strength, and knee fatigue index were not statistically different from discharge to follow-up (P>.05). Additionally, neuroprosthesis usage was consistent with subjects choosing to use the system on approximately half of the days during each monitoring period. Although the number of hours using the neuroprosthesis remained constant, subjects shifted their usage to more functional standing versus more maintenance exercise, suggesting that the subjects incorporated the neuroprosthesis into their lives. Safety and reliability of the system were demonstrated by electrode stability and a high component survivability rate (>90%).
CONCLUSIONS: This group of 15 subjects is the largest cohort of implanted lower-extremity neuroprosthetic exercise and standing system users. The safety and efficiency data from this group, and acceptance of the neuroprosthesis as demonstrated by continued usage, indicate that future efforts toward commercialization of a similar device may be warranted.
Authors:
Ronald J Triolo; Stephanie Nogan Bailey; Michael E Miller; Loretta M Rohde; James S Anderson; John A Davis; James J Abbas; Lisa A DiPonio; George P Forrest; David R Gater; Lynda J Yang
Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Archives of physical medicine and rehabilitation     Volume:  93     ISSN:  1532-821X     ISO Abbreviation:  Arch Phys Med Rehabil     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-04-30     Completed Date:  2012-07-24     Revised Date:  2014-07-28    
Medline Journal Info:
Nlm Unique ID:  2985158R     Medline TA:  Arch Phys Med Rehabil     Country:  United States    
Other Details:
Languages:  eng     Pagination:  896-904     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2012 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT00004445
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MeSH Terms
Descriptor/Qualifier:
Cervical Vertebrae
Female
Humans
Kaplan-Meier Estimate
Knee / physiology*
Longitudinal Studies
Lower Extremity / physiopathology
Male
Muscle Fatigue
Muscle Strength
Neural Prostheses* / adverse effects
Patient Acceptance of Health Care*
Prosthesis Failure
Prosthesis Implantation
Spinal Cord Injuries / physiopathology*,  rehabilitation,  surgery
Thoracic Vertebrae
Time Factors
Weight-Bearing / physiology
Grant Support
ID/Acronym/Agency:
UL1 RR024989/RR/NCRR NIH HHS; UL1 RR024989/RR/NCRR NIH HHS

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