Document Detail

Longitudinal monitoring of bone measured by quantitative multisite ultrasound in patients with Crohn's disease.
MedLine Citation:
PMID:  15681906     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Crohn's disease (CD) is characterized, among other features, by intestinal malabsorption of minerals, vitamins, and various food ingredients. This may cause a suboptimal peak bone mass and thereby susceptibility to osteoporosis at an early age. OBJECTIVE: Longitudinal measurement of bone in CD during active disease and during remission. DESIGN: We evaluated 24 patients with CD (16 males) 14 to 16 years of age longitudinally, every 3 months over 12 months, for disease activity. Longitudinal follow-up by quantitative ultrasound measurement using a bone sonometer (Sunlight Omnisense, Tel Aviv, Israel) that obtains axial speed of sound (SOS) was also performed. Eight of the CD patients were in remission (R-CD), characterized by accelerated weight and height gain and near-normal erythrocyte sedimentation rate and serum iron. Eight patients had active CD (A-CD), and 8 patients were under treatment with oxandrolone. RESULTS: By two-way repeated-measures analysis of variance, the change in SOS Z-score of tibia at 0, 6, and 12 months was as follows: -0.5 +/- 0.2 to -0.3 +/- 0.2, -0.6 +/- 0.2 to -1.0 +/- 0.5 and -0.6 +/- 0.2 to -0.4 +/- 0.2 in the remission, active disease, and oxandrolone-treated groups, respectively (P < 0.001). Similarly, the change in SOS Z-score of radius during the study was as follows: -0.5 +/- 0.3 to -0.6 +/- 0.3, -0.6 +/- 0.3 to -1.0 +/- 0.3 and -0.6 +/- 0.2 to -0.4 +/- 0.2 in the remission, active disease, and oxandrolone-treated groups, respectively (P < 0.001). While a small change over time in patients in remission was noted, SOS decreased in patients with active disease and increased in oxandrolone-treated patients. Despite the fact that SOS remained in the normative range in all patients, a clear deterioration was demonstrated for patients with active disease. CONCLUSIONS: We conclude that longitudinal follow-up of patients with active disease may detect an early pattern of deterioration in quality of bone.
Zvi Zadik; Tali Sinai; Amnon Zung; Ram Reifen
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of clinical gastroenterology     Volume:  39     ISSN:  0192-0790     ISO Abbreviation:  J. Clin. Gastroenterol.     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-01-31     Completed Date:  2005-04-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7910017     Medline TA:  J Clin Gastroenterol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  120-3     Citation Subset:  IM    
Pediatric Endocrine Unit, Kaplan Medical Center, Hadassah Medical School, Jerusalem, Israel.
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MeSH Terms
Anabolic Agents / therapeutic use
Analysis of Variance
Body Mass Index
Bone Density / physiology*
Crohn Disease / drug therapy,  metabolism,  ultrasonography*
Disease Progression
Follow-Up Studies
Oxandrolone / therapeutic use
Radius / metabolism,  ultrasonography*
Reproducibility of Results
Tibia / metabolism,  ultrasonography*
Reg. No./Substance:
0/Anabolic Agents; 53-39-4/Oxandrolone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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