| Longitudinal measures of lung function in infants with bronchopulmonary dysplasia. | |
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MedLine Citation:
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PMID: 21438170 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We previously demonstrated that infants with a history of bronchopulmonary dysplasia (BPD) exhibit airflow obstruction and air trapping. The purpose of this study was to assess longitudinal changes in pulmonary function in infants with a history of BPD over the first 3 years of life, and the relationship to somatic growth. Spirometry was measured using the raised volume rapid thoracoabdominal compression technique, and lung volumes measured by plethysmography. Eighteen infants (mean gestational age ± SD 27.3 ± 2.2 weeks, birthweight 971 ± 259 g) underwent two lung function studies. Average age at first test was 58.8 weeks. Spirometry demonstrated significant reductions in forced expiratory volume in 0.5 sec (FEV(0.5), 76.0 ± 15.9% predicted, Z-score -2.13 ± 1.69), forced expiratory flow at 75% of expired forced vital capacity (FEF(75), 54.8 ± 31.1%, -3.58 ± 2.73), and FEF(25-75) (67.8 ± 33.3%, -1.79 ± 1.76). Group mean total lung capacity (TLC) was in the low normal range (82.9 ± 13.5% predicted) and residual volume (RV)/TLC was mildly elevated (122.4 ± 38.2% predicted). Repeat testing was performed an average of 32.7 weeks after initial testing. At re-evaluation, group mean lung volumes and flows tracked at or near their previous values; thus, in general, there was a lack of catch-up growth. However, compared to infants with below average or average somatic growth (as represented by g/day), infants with above average growth showed significantly greater improvements in percent predicted FVC, FEV(0.5), TLC, and RV/TLC (all P < 0.05, ANOVA). We conclude that longitudinal measures of pulmonary function in infants and young children with BPD demonstrate significant airflow obstruction and modest restriction, which tends to persist with time. On the other hand, infants with above average somatic growth showed greater lung growth than their peers. Additional studies examining the effects of various nutritional regimens on lung function are warranted. |
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Authors:
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Amy G Filbrun; Antonia P Popova; Marisa J Linn; Nancy A McIntosh; Marc B Hershenson |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-11-17 |
Journal Detail:
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Title: Pediatric pulmonology Volume: 46 ISSN: 1099-0496 ISO Abbreviation: Pediatr. Pulmonol. Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-03-25 Completed Date: 2011-07-26 Revised Date: 2013-04-26 |
Medline Journal Info:
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Nlm Unique ID: 8510590 Medline TA: Pediatr Pulmonol Country: United States |
Other Details:
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Languages: eng Pagination: 369-75 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Wiley-Liss, Inc. |
Affiliation:
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Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, Michigan 48109-0212, USA. afilbrun@umich.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bronchopulmonary Dysplasia
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diagnosis,
physiopathology* Child, Preschool Female Humans Infant Infant, Newborn Longitudinal Studies Lung / physiopathology* Male Respiratory Function Tests |
| Grant Support | |
ID/Acronym/Agency:
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HL90134/HL/NHLBI NIH HHS; R01 HL079339/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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