Document Detail

Longitudinal investigation of energy expenditure in infants with cystic fibrosis.
MedLine Citation:
PMID:  12373612     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine when energy expenditure becomes elevated in infants with cystic fibrosis (CF). DESIGN: Longitudinal studies of total energy expenditure (TEE) using doubly labeled water were conducted in infants identified with CF by newborn screening through the first year of life. SETTING: Hospital and community based studies in Denver, Colorado, USA and Cambridge, UK. RESULTS: Eight of the 12 infants enrolled had begun enzyme therapy but were clinically asymptomatic. Four of the 12 infants were heterozygous for the delta F508 mutation, however no difference was seen in TEE from the remaining homozygous infants. TEE was compared to control cohorts at 2, 6 and 12 months of age. There was no difference from the control groups in TEE/kg fat free mass (FFM)/day at 2 months. However, by 6 months of age TEE/kg FFM/day in infants with CF exceeded that of age-matched controls by 25% (P<0.001). This elevation in TEE continued at 12 months of age exceeding that of controls by 30% (P<0.05). CONCLUSIONS: These results indicate that infants with CF have increased energy needs by 6 months of age and that early diagnosis alone does not prevent the development of increased caloric requirements. These findings emphasize the need for close nutritional monitoring to prevent suboptimal growth during infancy in this population. SPONSORSHIP: This research was supported by grant number 5 MO1 RR00069, General Clinical Research Centers Program, National Center for Research Resources, NIH.
P S W Davies; J M Erskine; K M Hambidge; F J Accurso
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  European journal of clinical nutrition     Volume:  56     ISSN:  0954-3007     ISO Abbreviation:  Eur J Clin Nutr     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-10-09     Completed Date:  2002-12-30     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8804070     Medline TA:  Eur J Clin Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  940-6     Citation Subset:  IM    
Children's Nutrition Research Centre, Department of Paediatrics and Child Health, University of Queensland, Royal Children's Hospital, Brisbane, Australia.
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MeSH Terms
Body Water / metabolism
Cohort Studies
Cystic Fibrosis / genetics,  metabolism*
Energy Metabolism*
Indicator Dilution Techniques
Infant, Newborn
Longitudinal Studies
Neonatal Screening
Grant Support

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