Document Detail


Longitudinal growth of infants born to HIV-1-infected mothers in Belo Horizonte, Brazil.
MedLine Citation:
PMID:  18503725     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To prospectively evaluate growth parameters assessed by weight and length in infected and uninfected infants born to HIV-1-infected mothers and followed from birth to 18 months. METHODS: A cohort consisting of ninety-seven uninfected and forty-two infected infants born to HIV-infected mothers enrolled from 1995 to 2004, and admitted during their first 3 months of life at a referral Pediatric AIDS Clinic in Belo Horizonte, Brazil. Infants were followed until 18 months of age. Data were analysed using mixed-effects linear regression models for weight and length fitted by restricted maximum likelihood. RESULTS: Infected infants contributed to 466 weight and 411 recumbent length measurements. Uninfected infants provided 924 weight and 907 length measurements. Mean birth weight and length were similar in both groups, 3.1 (sd 0.4) and 3.0 (sd 0.5) kg, and 48.7 (sd 1.4) and 48.8 (sd 2.9) cm for uninfected and infected infants, respectively. However, HIV-1 infection had an early impact in growth impairment: at 6 months of age, HIV-infected children were 1 kg lighter and 2 cm shorter than the uninfected. CONCLUSIONS: Growth faltering in weight, but not length, in HIV-infected children in Brazil is more marked than that reported in a European cohort, probably reflecting background nutritional deficiencies and concomitant infections. In these settings, early and aggressive nutritional management in HIV-1-infected infants should be a priority intervention associated with the antiretroviral therapy.
Authors:
Maria Arlene Fausto; Mariângela Carneiro; Carlos Maurício F Antunes; Enrico Antônio Colosimo; Jorge A Pinto
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-05-27
Journal Detail:
Title:  Public health nutrition     Volume:  12     ISSN:  1475-2727     ISO Abbreviation:  Public Health Nutr     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-05-20     Completed Date:  2009-07-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9808463     Medline TA:  Public Health Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  783-8     Citation Subset:  IM    
Affiliation:
Departamento de Alimentos, Escola de Nutrição, Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais 35400-000, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Body Height / physiology
Body Weight / physiology
Brazil
Case-Control Studies
Cohort Studies
Failure to Thrive / epidemiology*,  etiology,  virology
Female
Growth
HIV Infections / congenital*,  physiopathology
HIV-1*
Humans
Infant
Infant, Newborn / growth & development*
Infectious Disease Transmission, Vertical
Likelihood Functions
Linear Models
Male
Mothers
Pregnancy
Pregnancy Complications, Infectious / physiopathology*,  virology
Prospective Studies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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