| Longitudinal gray matter changes in multiple sclerosis-Differential scanner and overall disease-related effects. | |
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MedLine Citation:
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PMID: 21538703 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Voxel-based morphometry (VBM) has been used repeatedly in single-center studies to investigate regional gray matter (GM) atrophy in multiple sclerosis (MS). In multi-center trials, across-scanner variations might interfere with the detection of disease-specific structural abnormalities, thereby potentially limiting the use of VBM. Here we evaluated longitudinally inter-site differences and inter-site comparability of regional GM in MS using VBM. Baseline and follow up 3D T1-weighted magnetic resonance imaging (MRI) data of 248 relapsing-remitting (RR) MS patients, recruited in two clinical centers, (center1/2: n = 129/119; mean age 42.6 ± 10.7/43.3 ± 9.3; male:female 33:96/44:75; median disease duration 150 [72-222]/116 [60-156]) were acquired on two different 1.5T MR scanners. GM volume changes between baseline and year 2 while controlling for age, gender, disease duration, and global GM volume were analyzed. The main effect of time on regional GM volume was larger in data of center two as compared to center one in most of the brain regions. Differential effects of GM volume reductions occured in a number of GM regions of both hemispheres, in particular in the fronto-temporal and limbic cortex (cluster P corrected <0.05). Overall disease-related effects were found bilaterally in the cerebellum, uncus, inferior orbital gyrus, paracentral lobule, precuneus, inferior parietal lobule, and medial frontal gyrus (cluster P corrected <0.05). The differential effects were smaller as compared to the overall effects in these regions. These results suggest that the effects of different scanners on longitudinal GM volume differences were rather small and thus allow pooling of MR data and subsequent combined image analysis. Hum Brain Mapp, 2011. © 2011 Wiley-Liss, Inc. |
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Authors:
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Kerstin Bendfeldt; Louis Hofstetter; Pascal Kuster; Stefan Traud; Nicole Mueller-Lenke; Yvonne Naegelin; Ludwig Kappos; Achim Gass; Thomas E Nichols; Frederik Barkhof; Hugo Vrenken; Stefan D Roosendaal; Jeroen J G Geurts; Ernst-Wilhelm Radue; Stefan J Borgwardt |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-29 |
Journal Detail:
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Title: Human brain mapping Volume: - ISSN: 1097-0193 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-5-3 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9419065 Medline TA: Hum Brain Mapp Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Wiley-Liss, Inc. |
Affiliation:
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Medical Image Analysis Center (MIAC), University Hospital Basel, CH-4031 Basel, Switzerland. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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