| Longitudinal evaluation of cardiopulmonary performance during exercise after bone marrow transplantation in children. | |
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MedLine Citation:
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PMID: 10700686 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Abnormalities in cardiopulmonary performance during exercise have been reported in children after bone marrow transplantation (BMT). We sought to study changes in exercise performance over time in pediatric BMT survivors. STUDY DESIGN: We retrospectively reviewed the results of serial cardiopulmonary exercise tests performed by patients who had undergone BMT at our institution. Four measurements of cardiopulmonary function are reported: maximum cardiac index (MCI), maximal oxygen consumption (Max VO(2)), oxygen consumption at ventilatory threshold (VO(2) at VT), and maximum work (Max Work) performed. A linear mixed-effects model was fitted to assess changes in these parameters over time. RESULTS: Thirty-three patients performed 96 cardiopulmonary exercise tests. MCI and VO(2) at VT were depressed at initial testing and did not change over time. Max VO(2) increased by 4% per year to 69% predicted, and Max Work increased to 77% predicted at 6 years after BMT. CONCLUSIONS: In spite of an impaired cardiovascular response to exercise as indicated by the persistently low MCI, aerobic and physical working capacity increase. Improved Max VO(2) suggests that oxygen extraction at the musculoskeletal level becomes more efficient with recovery from BMT. This may represent a compensatory response to an impaired ability to increase cardiac output. |
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Authors:
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A N Hogarty; A Leahey; H Zhao; M D Hogarty; N Bunin; A Cnaan; S M Paridon |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of pediatrics Volume: 136 ISSN: 0022-3476 ISO Abbreviation: J. Pediatr. Publication Date: 2000 Mar |
Date Detail:
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Created Date: 2000-04-11 Completed Date: 2000-04-11 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 311-7 Citation Subset: AIM; IM |
Affiliation:
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Division of Cardiology, Division of Oncology, Division of Biostatistics and Epidemiology, and Department of Pediatrics, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Bone Marrow Transplantation / physiology* Child Child, Preschool Exercise* Female Forced Expiratory Volume* Heart Function Tests Hemoglobins / analysis Humans Longitudinal Studies Male Oxygen Consumption / physiology* Respiratory Function Tests Retrospective Studies |
| Grant Support | |
ID/Acronym/Agency:
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3M01 RR00240-33S2/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Hemoglobins |
| Comments/Corrections | |
Comment In:
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J Pediatr. 2000 Mar;136(3):280-2
[PMID:
10700680
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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