Document Detail


Longitudinal evaluation of allergen and culturable fungal concentrations in inner-city households.
MedLine Citation:
PMID:  18085481     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To characterize seasonal variation of three allergens (dust mite, cat, and cockroach) and total culturable fungi and to explore whether residential characteristics were associated with the concentrations of these agents, floor dust was collected from 47 inner-city homes in Minneapolis, Minnesota, over a 1-year period. A longitudinal analysis of allergen and fungal concentrations was carried out using mixed-effect models. Overall, relative humidity was a better predictor of allergen concentrations over time than indoor temperature. Seasonal variation of cat and cockroach allergens was negligible compared with the variability associated with residential characteristics such as race/ethnicity, family income, and the presence of cats. Fungal concentrations showed significant seasonal variation that outweighed the variability associated with residential characteristics. Less than 30% of the dust mite allergen and cockroach allergens concentrations were above limits of detection. Observed cockroach allergen concentrations were higher in Spanish- and Somali-speaking households than in English-speaking households, while English-speaking households had significantly higher cat allergen concentrations compared with the other language groups. The ratios of within-home to between-home variance for total culturable fungi, dust mite, cockroach, and cat allergen concentrations were 2.54, 1.91, 0.55, and 0.24, respectively. This ratio is used to predict the number of repeated measurements of each allergen required to robustly estimate long-term exposure estimates such that exposure misclassification bias is kept within acceptable limits. It is not clear whether repeated measurements of dust mite and cockroach allergens are required for long-term average exposure because of the large fraction of nondetects. It is concluded that a single measurement of cat allergen is a reasonable surrogate for long-term average exposure, since repeated measurements over time were highly correlated. Total culturable fungi will require greater than nine repeated measurements for robust assessment of long-term exposures because of low correlations in fungal measures over time.
Authors:
Sook Ja Cho; Gurumurthy Ramachandran; Jason Grengs; Andrew D Ryan; Lynn E Eberly; John L Adgate
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of occupational and environmental hygiene     Volume:  5     ISSN:  1545-9632     ISO Abbreviation:  J Occup Environ Hyg     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2007-12-18     Completed Date:  2008-04-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101189458     Medline TA:  J Occup Environ Hyg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  107-18     Citation Subset:  IM    
Affiliation:
Division of Environmental Health Sciences, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA.
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MeSH Terms
Descriptor/Qualifier:
Air Microbiology
Air Pollution, Indoor / analysis*
Allergens / isolation & purification*
Animals
Cats
Cockroaches
Dust / analysis*
Fungi / isolation & purification*
Hispanic Americans
Humans
Humidity
Longitudinal Studies
Minnesota
Poverty Areas
Pyroglyphidae
Questionnaires
Residence Characteristics
Risk Factors
Seasons
Somalia / ethnology
Chemical
Reg. No./Substance:
0/Allergens; 0/Dust

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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