| Longitudinal determination of serum placental protein 13 during development of preeclampsia. | |
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MedLine Citation:
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PMID: 18753763 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine maternal serum placental protein 13 (PP13) in normal pregnancy and preeclampsia. METHODS: A prospective, longitudinal study with 41 normal pregnant women, 18 cases with preterm delivery or cervix insufficiency and 4 with developing late-onset preeclampsia. Six hundred and sixty-six maternal blood samples were obtained every 2-4 weeks starting at 5-8 weeks gestation (10-12 samples/patient) and tested for serum PP13 by ELISA. RESULTS: In normal pregnant women delivering at term, median maternal serum PP13 levels were growing from 166 to 202 pg/ml and 382 pg/ml in the first, second and third trimester, respectively. Preeclamptic women had significantly reduced PP13 levels in the first trimester (multiples of median of 0.14 at 7-8 weeks; p = 0.005 compared to normal). PP13 in the third trimester was significantly higher compared to normal at 35-36 weeks with PP13 multiples of median of 1.79. CONCLUSION: This preliminary study indicates that low levels of PP13 in early pregnancy identify at-risk pregnancies, whereas high levels precede the syndrome in late pregnancy and suggest syncytiotrophoblast necrosis. |
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Authors:
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Berthold Huppertz; Marei Sammar; Ilana Chefetz; Peruka Neumaier-Wagner; Clemens Bartz; Hamutal Meiri |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-08-28 |
Journal Detail:
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Title: Fetal diagnosis and therapy Volume: 24 ISSN: 1421-9964 ISO Abbreviation: Fetal. Diagn. Ther. Publication Date: 2008 |
Date Detail:
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Created Date: 2008-10-21 Completed Date: 2009-01-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9107463 Medline TA: Fetal Diagn Ther Country: Switzerland |
Other Details:
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Languages: eng Pagination: 230-6 Citation Subset: IM |
Copyright Information:
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Copyright 2008 S. Karger AG, Basel. |
Affiliation:
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Institute of Cell Biology, Histology and Embryology, Centre of Molecular Medicine, Medical University of Graz, Graz, Austria. berthold.huppertz@meduni-graz.at |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Biological Markers / blood Female Galectins / blood* Humans Immunohistochemistry Longitudinal Studies Middle Aged Placenta / metabolism Pre-Eclampsia / blood Pregnancy Pregnancy Proteins / blood* Pregnancy Trimester, First / blood Pregnancy Trimester, Second / blood Pregnancy Trimester, Third / blood Prospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Galectins; 0/LGALS13 protein, human; 0/Pregnancy Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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