Document Detail


Longitudinal determination of serum placental protein 13 during development of preeclampsia.
MedLine Citation:
PMID:  18753763     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine maternal serum placental protein 13 (PP13) in normal pregnancy and preeclampsia. METHODS: A prospective, longitudinal study with 41 normal pregnant women, 18 cases with preterm delivery or cervix insufficiency and 4 with developing late-onset preeclampsia. Six hundred and sixty-six maternal blood samples were obtained every 2-4 weeks starting at 5-8 weeks gestation (10-12 samples/patient) and tested for serum PP13 by ELISA. RESULTS: In normal pregnant women delivering at term, median maternal serum PP13 levels were growing from 166 to 202 pg/ml and 382 pg/ml in the first, second and third trimester, respectively. Preeclamptic women had significantly reduced PP13 levels in the first trimester (multiples of median of 0.14 at 7-8 weeks; p = 0.005 compared to normal). PP13 in the third trimester was significantly higher compared to normal at 35-36 weeks with PP13 multiples of median of 1.79. CONCLUSION: This preliminary study indicates that low levels of PP13 in early pregnancy identify at-risk pregnancies, whereas high levels precede the syndrome in late pregnancy and suggest syncytiotrophoblast necrosis.
Authors:
Berthold Huppertz; Marei Sammar; Ilana Chefetz; Peruka Neumaier-Wagner; Clemens Bartz; Hamutal Meiri
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-08-28
Journal Detail:
Title:  Fetal diagnosis and therapy     Volume:  24     ISSN:  1421-9964     ISO Abbreviation:  Fetal. Diagn. Ther.     Publication Date:  2008  
Date Detail:
Created Date:  2008-10-21     Completed Date:  2009-01-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107463     Medline TA:  Fetal Diagn Ther     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  230-6     Citation Subset:  IM    
Copyright Information:
Copyright 2008 S. Karger AG, Basel.
Affiliation:
Institute of Cell Biology, Histology and Embryology, Centre of Molecular Medicine, Medical University of Graz, Graz, Austria. berthold.huppertz@meduni-graz.at
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Biological Markers / blood
Female
Galectins / blood*
Humans
Immunohistochemistry
Longitudinal Studies
Middle Aged
Placenta / metabolism
Pre-Eclampsia / blood
Pregnancy
Pregnancy Proteins / blood*
Pregnancy Trimester, First / blood
Pregnancy Trimester, Second / blood
Pregnancy Trimester, Third / blood
Prospective Studies
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Galectins; 0/LGALS13 protein, human; 0/Pregnancy Proteins

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