| Longitudinal changes of structural connectivity in traumatic axonal injury. | |
| | |
MedLine Citation:
|
PMID: 21813787 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVES: To identify structural connectivity change occurring during the first 6 months after traumatic brain injury and to evaluate the utility of diffusion tensor tractography for predicting long-term outcome. METHODS: The participants were 28 patients with mild to severe traumatic axonal injury and 20 age- and sex-matched healthy control subjects. Neuroimaging was obtained 0-9 days postinjury for acute scans and 6-14 months postinjury for chronic scans. Long-term outcome was evaluated on the day of the chronic scan. Twenty-eight fiber regions of 9 major white matter structures were reconstructed, and reliable tractography measurements were determined and used. RESULTS: Although most (23 of 28) patients had severe brain injury, their long-term outcome ranged from good recovery (16 patients) to moderately (5 patients) and severely disabled (7 patients). In concordance with the diverse outcome, the white matter change in patients was heterogeneous, ranging from improved structural connectivity, through no change, to deteriorated connectivity. At the group level, all 9 fiber tracts deteriorated significantly with 7 (corpus callosum, cingulum, angular bundle, cerebral peduncular fibers, uncinate fasciculus, and inferior longitudinal and fronto-occipital fasciculi) showing structural damage acutely and 2 (fornix body and left arcuate fasciculus) chronically. Importantly, the amount of change in tractography measurements correlated with patients' long-term outcome. Acute tractography measurements were able to predict patients' learning and memory performance; chronic measurements also determined performance on processing speed and executive function. CONCLUSIONS: Diffusion tensor tractography is a valuable tool for identifying structural connectivity changes occurring between the acute and chronic stages of traumatic brain injury and for predicting patients' long-term outcome. |
| | |
Authors:
|
J Y Wang; K Bakhadirov; H Abdi; M D Devous; C D Marquez de la Plata; C Moore; C J Madden; R Diaz-Arrastia |
Related Documents
:
|
21756037 - Monoclonal b-lymphocytosis: demographics, nature and subclassification in 414 community... 20383667 - Mitochondrial dysfunction induced by statin contributes to endothelial dysfunction in p... 22569187 - Neural correlates of moral reasoning in autism spectrum disorder. 22139027 - The relationship between d-dimer level and the development of atrial fibrillation in pa... 12693777 - Use of methylphenidate for attention-deficit hyperactivity disorder in patients with ep... 11711837 - Charles bonnet syndrome in glaucoma patients with low vision. |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. Date: 2011-08-03 |
Journal Detail:
|
Title: Neurology Volume: 77 ISSN: 1526-632X ISO Abbreviation: Neurology Publication Date: 2011 Aug |
Date Detail:
|
Created Date: 2011-08-30 Completed Date: 2011-10-27 Revised Date: 2012-09-27 |
Medline Journal Info:
|
Nlm Unique ID: 0401060 Medline TA: Neurology Country: United States |
Other Details:
|
Languages: eng Pagination: 818-26 Citation Subset: AIM; IM |
Affiliation:
|
Department of Cognition and Neuroscience, University of Texas, Dallas, TX, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Brain Injuries / complications, pathology Diffuse Axonal Injury / etiology, pathology* Diffusion Tensor Imaging* Female Follow-Up Studies Humans Longitudinal Studies Male Middle Aged Nerve Fibers, Myelinated / pathology* Young Adult |
| Grant Support | |
ID/Acronym/Agency:
|
K23-NS060827/NS/NINDS NIH HHS; R01-HD48179/HD/NICHD NIH HHS; U01-HD042652/HD/NICHD NIH HHS |
| Comments/Corrections | |
Comment In:
|
Neurology. 2011 Aug 30;77(9):810-1
[PMID:
21813789
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Retinal atrophy correlates with fMRI response in patients with recovered optic neuritis.
Next Document: Azathioprine: Tolerability, efficacy, and predictors of benefit in neuromyelitis optica.