Document Detail

Longitudinal changes of pulmonary function and bronchial responsiveness in cough-variant asthma treated with bronchodilators alone.
MedLine Citation:
PMID:  17176782     Owner:  NLM     Status:  MEDLINE    
Cough due to cough-variant asthma (CVA) responds well to bronchodilators such as beta 2 adrenergic agonists. The aim of this study was to assess longitudinal changes of pulmonary function and bronchial responsiveness in CVA, which was treated with bronchodilators alone. Seventeen CVA patients recorded intensity and frequency of cough every day. Spirometry and provocative concentration of methacholine causing a 20% fall in forced expiratory volume in 1 second (PC20) were measured in the run-in period and after cough almost completely relieved on therapy. Cough score had improved within 2 weeks after the initiation of bronchodilator therapy. Forced expiratory volume in one second (FEV1) was significantly increased from 2.7 +/-0.7 L in the run-in period to 2.8+/-0.7 L after improvement of cough. However, the geometric mean (GSEM) PC20 value did not change from the run-in period [1542 (GSEM 1.29) microg/mL] to the time of improvement [2600 (GSEM 1.43) microg/mL]. Mildly increased bronchial responsiveness in CVA does not improve when only bronchodilator therapy is carried out. Because bronchial hyperresponsiveness has been shown to be a risk factor for typical asthma onset from CVA, the effect of inhaled corticosteroids on the longitudinal changes in bronchial responsiveness should be examined.
Kouichi Nobata; Masaki Fujimura; Hiroshi Tsuji; Yoshihisa Ishiura; Shigeharu Myou; Shinji Nakao; Eisuke Takazakura
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Allergy and asthma proceedings : the official journal of regional and state allergy societies     Volume:  27     ISSN:  1088-5412     ISO Abbreviation:  Allergy Asthma Proc     Publication Date:    2006 Nov-Dec
Date Detail:
Created Date:  2006-12-20     Completed Date:  2007-02-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9603640     Medline TA:  Allergy Asthma Proc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  479-85     Citation Subset:  IM    
Department of Internal Medicine, Kurobe City Hospital, Kurobe, Japan.
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MeSH Terms
Asthma / complications,  drug therapy*,  physiopathology
Bronchi / drug effects*,  physiology
Bronchial Hyperreactivity / drug therapy
Bronchodilator Agents / therapeutic use*
Cough / drug therapy*,  etiology,  physiopathology
Longitudinal Studies
Lung / drug effects*,  physiology
Middle Aged
Prospective Studies
Reg. No./Substance:
0/Bronchodilator Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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