| Longitudinal changes of metabolites in frontal lobes after hemorrhagic stroke of basal ganglia: a proton magnetic resonance spectroscopy study. | |
| | |
MedLine Citation:
|
PMID: 11588307 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND AND PURPOSE: We investigated serial metabolic changes in frontal lobes of patients with deep intracerebral hemorrhage (ICH) to examine the correlation between N-acetylaspartate (NAA) and degree of motor impairment or clinical outcome. METHODS:- Twenty patients with deep ICH were examined with proton magnetic resonance spectroscopy with the application of a multivoxel method (1 voxel=10x10x20 mm; 64 voxels). NAA/creatine ratios in the white matter of the primary motor and premotor areas on both sides were measured sequentially: within 48 hours, at 2 weeks, and 1 month after onset. The National Institutes of Health Stroke Scale and Barthel Index for disability were measured for each patient. RESULTS:- In the primary motor area on the affected side, where the hematoma did not extend, the NAA/creatine ratio decreased sequentially. At 48 hours and 2 weeks after onset, a negative correlation was detected between NAA/creatine and hematoma volume, but there was no correlation 1 month later. At 2 weeks, NAA/creatine correlated negatively with motor impairment (r=-0.750), and there was a significant correlation with clinical outcome as early as 2 weeks after onset (r=0.954). These sequential changes of NAA/creatine varied according to patients' long-term clinical outcome. Patients with poor outcome demonstrated notable reduction of NAA/creatine over the bilateral frontal lobes. CONCLUSIONS:- The delayed gradual reduction of NAA/creatine ratio in the frontal lobes correlates with motor deficit and clinical outcome after deep ICH, suggesting that the neural networks in the frontal lobe could be important for recovery. |
| | |
Authors:
|
M Kobayashi; H Takayama; S Suga; B Mihara |
Related Documents
:
|
17804017 - Investigation of hsv-1, hsv-2, cmv, hhv-6 and hhv-8 dna by real-time pcr in surgical re... 16529617 - Suppressive efficacy by a commercially available blue lens on ppr in 610 photosensitive... 19815357 - Characteristics of the synchronous occipital and frontopolar spike phenomenon in panayi... 508147 - Facial recognition in patients with focal brain lesions. 9869787 - Interferon-induced protein 10 and interleukin 8. c-x-c chemokines present in proliferat... 18609077 - Transient elevation of neutrophil proteinases in induced sputum during copd exacerbation. |
Publication Detail:
|
Type: Clinical Trial; Comparative Study; Journal Article |
Journal Detail:
|
Title: Stroke; a journal of cerebral circulation Volume: 32 ISSN: 1524-4628 ISO Abbreviation: Stroke Publication Date: 2001 Oct |
Date Detail:
|
Created Date: 2001-10-05 Completed Date: 2001-11-01 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0235266 Medline TA: Stroke Country: United States |
Other Details:
|
Languages: eng Pagination: 2237-45 Citation Subset: IM |
Affiliation:
|
Department of Neurosurgery, Institute of Brain and Blood Vessels, Mihara Memorial Hospital, Isesaki, Japan. mkobayas@caregroup.harvard.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Aged, 80 and over Aspartic Acid / analogs & derivatives, metabolism Basal Ganglia Hemorrhage / complications, diagnosis*, metabolism*, therapy Creatine / metabolism Disease Progression Female Frontal Lobe / metabolism* Humans Magnetic Resonance Imaging Magnetic Resonance Spectroscopy* Male Middle Aged Predictive Value of Tests Severity of Illness Index Stroke / complications, diagnosis*, metabolism*, therapy Treatment Outcome |
| Chemical | |
Reg. No./Substance:
|
56-84-8/Aspartic Acid; 57-00-1/Creatine; 997-55-7/N-acetylaspartate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Validating the Questionnaire for Verifying Stroke-Free Status (QVSFS) by neurological history and ex...
Next Document: Evaluation of risk factors for stroke/embolism and of complications due to anticoagulant therapy in ...