| Longitudinal changes of insulin-like growth factors and their binding proteins throughout normal pregnancy. | |
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MedLine Citation:
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PMID: 15117436 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Insulin-like growth factors (IGFs) are anabolic proteins that are essential regulators of cell division, differentiation and growth. We describe the longitudinal changes in IGF-I, IGF-II and the binding proteins IGFBP-1, -2 and -3 before and during normal pregnancy. METHOD: Serum samples were taken before conception and then at 12, 24 and 36 weeks of gestation in 41 healthy women with uncomplicated pregnancies. We measured IGF-I using an automated chemiluminescent method, IGF-II and IGFBP-2 using in-house radioimmunoassays (RIAs), and IGFBP-1 and IGFBP-3 using commercial enzyme-linked immunosorbent assay (ELISA) and RIA kits, respectively. Because of the potential haemodilution effects during pregnancy, albumin was also measured in all samples. RESULTS: There was a significant fall in IGF-I during the first (36%) and second trimesters (21%) followed by an increase of 25% at 36 weeks. During pregnancy, the mean IGF-II concentrations fell by 12% at 12 weeks, 8% at 24 and 8% at 36 weeks compared with pre-conception values. When IGF-II results were adjusted for the haemodilution of pregnancy, its concentrations increased. During pregnancy, there was a rapid increase in mean IGFBP-1 levels by 17-fold (12 weeks), 24-fold (24 weeks) and 25-fold (36 weeks). IGFBP-2 concentrations fell after conception but started to increase towards term. This increase was more significant when adjusted for haemodilution. In contrast, IGFBP-3 concentrations increased significantly throughout pregnancy. CONCLUSION: Our data on the physiological changes of IGFs and their binding proteins add further evidence of the vital roles of these hormones throughout normal pregnancy. |
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Authors:
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John M Monaghan; Ian M Godber; Nigel Lawson; Malveen Kaur; Gwen Wark; Derrick Teale; David J Hosking |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annals of clinical biochemistry Volume: 41 ISSN: 0004-5632 ISO Abbreviation: Ann. Clin. Biochem. Publication Date: 2004 May |
Date Detail:
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Created Date: 2004-04-30 Completed Date: 2004-11-29 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0324055 Medline TA: Ann Clin Biochem Country: England |
Other Details:
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Languages: eng Pagination: 220-6 Citation Subset: IM |
Affiliation:
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Department of Clinical Chemistry, Nottingham City Hospital, Nottingham NG5 1PB, UK. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Biological Markers
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blood Birth Weight Chemiluminescent Measurements Enzyme-Linked Immunosorbent Assay Female Gestational Age Hemodilution Humans Infant, Newborn Insulin-Like Growth Factor Binding Protein 1 / blood Insulin-Like Growth Factor Binding Protein 2 / blood Insulin-Like Growth Factor Binding Protein 3 / blood Longitudinal Studies* Male Pregnancy / blood* Radioimmunoassay Somatomedins / analysis*, metabolism Statistics as Topic |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Insulin-Like Growth Factor Binding Protein 1; 0/Insulin-Like Growth Factor Binding Protein 2; 0/Insulin-Like Growth Factor Binding Protein 3; 0/Somatomedins |
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