Document Detail


Longitudinal changes of insulin-like growth factors and their binding proteins throughout normal pregnancy.
MedLine Citation:
PMID:  15117436     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Insulin-like growth factors (IGFs) are anabolic proteins that are essential regulators of cell division, differentiation and growth. We describe the longitudinal changes in IGF-I, IGF-II and the binding proteins IGFBP-1, -2 and -3 before and during normal pregnancy. METHOD: Serum samples were taken before conception and then at 12, 24 and 36 weeks of gestation in 41 healthy women with uncomplicated pregnancies. We measured IGF-I using an automated chemiluminescent method, IGF-II and IGFBP-2 using in-house radioimmunoassays (RIAs), and IGFBP-1 and IGFBP-3 using commercial enzyme-linked immunosorbent assay (ELISA) and RIA kits, respectively. Because of the potential haemodilution effects during pregnancy, albumin was also measured in all samples. RESULTS: There was a significant fall in IGF-I during the first (36%) and second trimesters (21%) followed by an increase of 25% at 36 weeks. During pregnancy, the mean IGF-II concentrations fell by 12% at 12 weeks, 8% at 24 and 8% at 36 weeks compared with pre-conception values. When IGF-II results were adjusted for the haemodilution of pregnancy, its concentrations increased. During pregnancy, there was a rapid increase in mean IGFBP-1 levels by 17-fold (12 weeks), 24-fold (24 weeks) and 25-fold (36 weeks). IGFBP-2 concentrations fell after conception but started to increase towards term. This increase was more significant when adjusted for haemodilution. In contrast, IGFBP-3 concentrations increased significantly throughout pregnancy. CONCLUSION: Our data on the physiological changes of IGFs and their binding proteins add further evidence of the vital roles of these hormones throughout normal pregnancy.
Authors:
John M Monaghan; Ian M Godber; Nigel Lawson; Malveen Kaur; Gwen Wark; Derrick Teale; David J Hosking
Related Documents :
22604746 - Pathological cases of the month: case 1.
2518706 - First trimester maternal serum lysosomal enzymes: implications for carrier testing and ...
920766 - Further investigation on the predictive value of human placental lactogen in high-risk ...
3910076 - Serum beta 2-microglobulin: a real improvement in the management of multiple myeloma?
24591916 - Influence of cumulus cell coculture and cumulusaided embryo transfer on embryonic devel...
8299776 - Transcervical fallopian tube catheterization and recanalization for proximal tubal obst...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of clinical biochemistry     Volume:  41     ISSN:  0004-5632     ISO Abbreviation:  Ann. Clin. Biochem.     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-04-30     Completed Date:  2004-11-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0324055     Medline TA:  Ann Clin Biochem     Country:  England    
Other Details:
Languages:  eng     Pagination:  220-6     Citation Subset:  IM    
Affiliation:
Department of Clinical Chemistry, Nottingham City Hospital, Nottingham NG5 1PB, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Biological Markers / blood
Birth Weight
Chemiluminescent Measurements
Enzyme-Linked Immunosorbent Assay
Female
Gestational Age
Hemodilution
Humans
Infant, Newborn
Insulin-Like Growth Factor Binding Protein 1 / blood
Insulin-Like Growth Factor Binding Protein 2 / blood
Insulin-Like Growth Factor Binding Protein 3 / blood
Longitudinal Studies*
Male
Pregnancy / blood*
Radioimmunoassay
Somatomedins / analysis*,  metabolism
Statistics as Topic
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Insulin-Like Growth Factor Binding Protein 1; 0/Insulin-Like Growth Factor Binding Protein 2; 0/Insulin-Like Growth Factor Binding Protein 3; 0/Somatomedins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Composition of LDL particle discriminates between hypercholesterolaemic persons with and without sym...
Next Document:  Can the addition of interpretative comments to laboratory reports influence outcome? An example invo...