Document Detail


Longitudinal changes in uterine artery Doppler and blood pressure and the risk of preeclampsia.
MedLine Citation:
PMID:  24265180     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: The aim of this study was to investigate the longitudinal changes in uterine artery mean pulsatility index (Ut-PI) and mean arterial pressure (MAP) in women who subsequently develop preeclampsia (PE) and gestational hypertension (GH).
METHODS: This was a prospective longitudinal study in singleton pregnancies identified by screening at 11(+0) -13(+6)  weeks' gestation as being at high-risk for PE. Measurements of Ut-PI and MAP were taken every four weeks until delivery and they were compared in pregnancies that developed preterm-PE, requiring delivery before 37 weeks, term-PE and GH with those that remained normotensive.
RESULTS: In the normal outcome group Ut-PI decreased with gestational age and MAP decreased between 12 and 24 weeks and then increased. In preterm-PE, compared to the normal group, Ut-PI and MAP were higher from early pregnancy and the difference for both increased with gestational age. In term-PE, Ut-PI was significantly increased only from 33 weeks onwards and MAP was increased from 12 weeks but the difference from normal did not increase with gestation. In GH, Ut-PI was not significantly different from normal but MAP was higher from 12 weeks.
CONCLUSION: The study describes the temporal changes in Ut-PI and MAP in normal pregnancies and in those that develop PE and GH.
Authors:
Asma Khalil; Rosario Garcia-Mandujano; Nerea Maiz; Mohamed Elkhaouli; Kypros H Nicolaides
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-11-21
Journal Detail:
Title:  Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology     Volume:  -     ISSN:  1469-0705     ISO Abbreviation:  Ultrasound Obstet Gynecol     Publication Date:  2013 Nov 
Date Detail:
Created Date:  2013-11-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9108340     Medline TA:  Ultrasound Obstet Gynecol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
This article is protected by copyright. All rights reserved.
Affiliation:
Department of Fetal Medicine, Institute for Women's Health, University College London Hospitals, London, UK.
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