Document Detail


Longitudinal changes in resting-state brain activity in a capsular infarct model.
MedLine Citation:
PMID:  25352047     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Strokes attributable to subcortical infarcts have been increasing recently in elderly patients. To gain insight how this lesion influences the motor outcome and responds to rehabilitative training, we used circumscribed photothrombotic capsular infarct models on 36 Sprague-Dawley rats (24 experimental and 12 sham-operated). We used 2-deoxy-2-[(18)F]-fluoro-D-glucose-micro positron emission tomography (FDG-microPET) to assess longitudinal changes in resting-state brain activity (rs-BA) and daily single-pellet reaching task (SPRT) trainings to evaluate motor recovery. Longitudinal FDG-microPET results showed that capsular infarct resulted in a persistent decrease in rs-BA in bilateral sensory and auditory cortices, and ipsilesional motor cortex, thalamus, and inferior colliculus (P<0.0025, false discovery rate (FDR) q<0.05). The decreased rs-BA is compatible with diaschisis and contributes to manifest the malfunctions of lesion-specific functional connectivity. In contrast, capsular infarct resulted in increase of rs-BA in the ipsilesional internal capsule, and contralesional red nucleus and ventral hippocampus in recovery group (P<0.0025, FDR q<0.05), implying that remaining subcortical structures have an important role in conducting the recovery process in capsular infarct. The SPRT training facilitated motor recovery only in rats with an incomplete destruction of the posterior limb of the internal capsule (PLIC) (Pearson's correlation, P<0.05). Alternative therapeutic interventions are required to enhance the potential for recovery in capsular infarct with complete destruction of PLIC.Journal of Cerebral Blood Flow & Metabolism advance online publication, 29 October 2014; doi:10.1038/jcbfm.2014.178.
Authors:
Donghyeon Kim; Ra Gyung Kim; Hyung-Sun Kim; Jin-Myung Kim; Sung Chan Jun; Boreom Lee; Hang Joon Jo; Pedro R Neto; Min-Cheol Lee; Hyoung-Ihl Kim
Related Documents :
24357507 - Biomarkers and acute coronary syndromes: an update.
22670207 - Visualization and simulated surgery of the left ventricle in the virtual pathological h...
8443207 - Coronary artery disease after heart transplantation: timing of coronary arteriography.
23160517 - Noninvasive image derived heart input function for cmrglc measurements in small animal ...
1388327 - Effect of gallopamil on electrophysiologic abnormalities and ventricular arrhythmias as...
1999787 - Changes in cardiac function during extracorporeal membrane oxygenation for persistent p...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-10-29
Journal Detail:
Title:  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism     Volume:  -     ISSN:  1559-7016     ISO Abbreviation:  J. Cereb. Blood Flow Metab.     Publication Date:  2014 Oct 
Date Detail:
Created Date:  2014-10-29     Completed Date:  -     Revised Date:  2014-10-30    
Medline Journal Info:
Nlm Unique ID:  8112566     Medline TA:  J Cereb Blood Flow Metab     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Phenylketonuria: brain phenylalanine concentrations relate inversely to cerebral protein synthesis.
Next Document:  miR?542?3p overexpression is associated with enhanced osteosarcoma cell proliferation and migration ...