Document Detail

Longitudinal changes in QT interval variability and rate adaptation in pregnancies with normal and abnormal uterine perfusion.
MedLine Citation:
PMID:  20224570     Owner:  NLM     Status:  MEDLINE    
The maternal heart significantly adapts to the circulatory needs of pregnancy, but the effect of pregnancy on ventricular repolarization is poorly understood. The aim of this study was to quantify longitudinal changes in ventricular repolarization during pregnancy. Monthly electrocardiographs (ECGs) were recorded in 32 pregnant women with normal uterine perfusion and 32 pregnant women with abnormal perfusion, starting from the 20th week of gestation until 3 days postpartum. Ventricular repolarization was assessed through various QT interval variability and heart rate adaptation measures. The pregnancy outcomes of all women with normal perfusion were normal. Among pregnancies with abnormal uterine perfusion, 15 pregnancy outcomes were normal, but 17 pregnancies developed preeclampsia and/or small-for-gestational-age infants. In pregnancies with normal perfusion, the QT(c) interval was unaltered, but the QT interval-heart rate hysteresis lag was shorter and the QT interval-heart rate regression residual was higher compared with those of a control group of 10 healthy non-pregnant women. Pregnancies with abnormal uterine perfusion that developed pathological outcomes showed significantly smaller QT interval-heart rate regression residuals and a trend towards shorter QT(c) intervals compared with pregnant women with normal perfusion. In conclusion, pregnancy has a significant effect on ventricular repolarization. Pregnancies with abnormal uterine perfusion and subsequent pathological outcomes are paralleled by changes in ventricular repolarization that precede clinical symptoms.
Mathias Baumert; Andrea Seeck; Renaldo Faber; Eugene Nalivaiko; Andreas Voss
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-03-12
Journal Detail:
Title:  Hypertension research : official journal of the Japanese Society of Hypertension     Volume:  33     ISSN:  1348-4214     ISO Abbreviation:  Hypertens. Res.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-04     Completed Date:  2010-09-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9307690     Medline TA:  Hypertens Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  555-60     Citation Subset:  IM    
School of Paediatrics and Reproductive Health and School of Medicine, University of Adelaide, Adelaide, Australia.
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MeSH Terms
Adaptation, Physiological*
Arrhythmias, Cardiac / physiopathology*
Heart Rate / physiology*
Heart Ventricles / physiopathology*
Infant, Newborn
Infant, Small for Gestational Age
Longitudinal Studies
Pre-Eclampsia / physiopathology
Pregnancy Complications, Cardiovascular / physiopathology*
Pregnancy Outcome
Uterus / blood supply*
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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