Document Detail

Longitudinal cerebrospinal fluid tau load increases in mild cognitive impairment.
MedLine Citation:
PMID:  12429378     Owner:  NLM     Status:  MEDLINE    
Cross-sectional cerebrospinal fluid (CSF) levels of tau and amyloid (A) beta (beta) are of diagnostic importance for Alzheimer's disease (AD) and mild cognitive impairment (MCI). However, most longitudinal studies of tau fail to demonstrate progression. Because predominantly brain-derived proteins such as tau, have higher ventricle to lumbar ratios, we hypothesized that adjusting for the ventricular enlargement of AD would correct for the dilution of tau, and improve detection of longitudinal change. Abeta which is not exclusively brain derived, shows a ratio <1, and no benefit was expected from adjustment. In a 1 year longitudinal study of eight MCI and ten controls, we examined CSF levels of hyperphosphorylated (P) tau231, Abeta40, and Abeta42. In cross-section, MCI patients showed elevated Ptau231 and Abeta40 levels, and greater ventricular volumes. Longitudinally, only after adjusting for the ventricular volume and only for Ptau231, were increases seen in MCI. Further studies are warranted on mechanisms of tau clearance and on using imaging to interpret CSF studies.
M J de Leon; S Segal; C Y Tarshish; S DeSanti; R Zinkowski; P D Mehta; A Convit; C Caraos; H Rusinek; W Tsui; L A Saint Louis; J DeBernardis; D Kerkman; F Qadri; A Gary; P Lesbre; T Wisniewski; J Poirier; P Davies
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neuroscience letters     Volume:  333     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-11-13     Completed Date:  2003-01-30     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  183-6     Citation Subset:  IM    
Copyright Information:
Copyright 2002 Elsevier Science Ireland Ltd.
Centre for Brain Health, Department of Psychiatry, New York University School of Medicine, NY 10016, USA.
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MeSH Terms
Amyloid beta-Protein / cerebrospinal fluid*
Biological Markers
Cognition Disorders / cerebrospinal fluid*,  diagnosis,  psychology
Cross-Sectional Studies
Enzyme-Linked Immunosorbent Assay / methods
Follow-Up Studies
Longitudinal Studies
Magnetic Resonance Imaging
Middle Aged
Peptide Fragments / cerebrospinal fluid
Reference Values
Severity of Illness Index
Statistics, Nonparametric
tau Proteins / cerebrospinal fluid*
Grant Support
Reg. No./Substance:
0/Amyloid beta-Protein; 0/Biological Markers; 0/Peptide Fragments; 0/tau Proteins

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