| Longitudinal cerebrospinal fluid tau load increases in mild cognitive impairment. | |
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MedLine Citation:
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PMID: 12429378 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cross-sectional cerebrospinal fluid (CSF) levels of tau and amyloid (A) beta (beta) are of diagnostic importance for Alzheimer's disease (AD) and mild cognitive impairment (MCI). However, most longitudinal studies of tau fail to demonstrate progression. Because predominantly brain-derived proteins such as tau, have higher ventricle to lumbar ratios, we hypothesized that adjusting for the ventricular enlargement of AD would correct for the dilution of tau, and improve detection of longitudinal change. Abeta which is not exclusively brain derived, shows a ratio <1, and no benefit was expected from adjustment. In a 1 year longitudinal study of eight MCI and ten controls, we examined CSF levels of hyperphosphorylated (P) tau231, Abeta40, and Abeta42. In cross-section, MCI patients showed elevated Ptau231 and Abeta40 levels, and greater ventricular volumes. Longitudinally, only after adjusting for the ventricular volume and only for Ptau231, were increases seen in MCI. Further studies are warranted on mechanisms of tau clearance and on using imaging to interpret CSF studies. |
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Authors:
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M J de Leon; S Segal; C Y Tarshish; S DeSanti; R Zinkowski; P D Mehta; A Convit; C Caraos; H Rusinek; W Tsui; L A Saint Louis; J DeBernardis; D Kerkman; F Qadri; A Gary; P Lesbre; T Wisniewski; J Poirier; P Davies |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Neuroscience letters Volume: 333 ISSN: 0304-3940 ISO Abbreviation: Neurosci. Lett. Publication Date: 2002 Nov |
Date Detail:
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Created Date: 2002-11-13 Completed Date: 2003-01-30 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: Ireland |
Other Details:
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Languages: eng Pagination: 183-6 Citation Subset: IM |
Copyright Information:
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Copyright 2002 Elsevier Science Ireland Ltd. |
Affiliation:
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Centre for Brain Health, Department of Psychiatry, New York University School of Medicine, NY 10016, USA. mony.deleon@med.nyu.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Amyloid beta-Protein / cerebrospinal fluid* Biological Markers Cognition Disorders / cerebrospinal fluid*, diagnosis, psychology Cross-Sectional Studies Enzyme-Linked Immunosorbent Assay / methods Female Follow-Up Studies Humans Longitudinal Studies Magnetic Resonance Imaging Male Middle Aged Peptide Fragments / cerebrospinal fluid Reference Values Severity of Illness Index Statistics, Nonparametric tau Proteins / cerebrospinal fluid* |
| Grant Support | |
ID/Acronym/Agency:
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AG03051/AG/NIA NIH HHS; AG08051/AG/NIA NIH HHS; AG21201/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Amyloid beta-Protein; 0/Biological Markers; 0/Peptide Fragments; 0/tau Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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