| Longitudinal cerebral blood flow changes during speech in hereditary ataxia. | |
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MedLine Citation:
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PMID: 20417959 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The hereditary ataxias constitute a group of degenerative diseases that progress over years or decades. With principal pathology involving the cerebellum, dysarthria is an early feature of many of the ataxias. Positron emission tomography was used to study regional cerebral blood flow changes during speech production over a 21 month period in a group of seven right-handed subjects with hereditary ataxia (6 females and 1 male, 3 SCA1 and 4 SCA5, aged 38.3+/-18.9 years). The decline in blood flow was greatest in cerebellar regions. In contrast, blood flow actually increased during speech production in the classic speech area (Broca's area) but not in its right-hemisphere homologue at the second evaluation. This increase in cortical flow may have been compensatory for cerebellar degeneration as speech intelligibility did not decline significantly during this period. Compensation was not complete, though, as syllable timing shifted in the direction of equal syllable duration, one of the characteristics of ataxic dysarthria. These results are consistent with previous functional imaging studies of ataxia demonstrating a pattern of brain activity that reflects both loss of function and relative compensation when clinical signs and symptoms are still mild. The combination of disease-relevant tasks, behavioral measurement, and functional imaging may provide insight into the early changes associated with neurodegenerative disease. |
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Authors:
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John J Sidtis; Stephen C Strother; Ansam Groshong; Ansam Naoum; David A Rottenberg; Christopher Gomez |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-04-24 |
Journal Detail:
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Title: Brain and language Volume: 114 ISSN: 1090-2155 ISO Abbreviation: Brain Lang Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-05-04 Completed Date: 2010-07-19 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 7506220 Medline TA: Brain Lang Country: United States |
Other Details:
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Languages: eng Pagination: 43-51 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Brain and Behavior Laboratory, Geriatrics Division, Nathan Kline Institute, 140 Old Orangeburg Road, Orangeburg, NY 10962, United States. john.sidtis@nyu.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Brain / physiopathology*, radionuclide imaging Brain Mapping Cerebrovascular Circulation / physiology* Disease Progression Female Humans Longitudinal Studies Male Middle Aged Neurologic Examination Positron-Emission Tomography Speech / physiology* Spinocerebellar Degenerations / physiopathology*, radionuclide imaging Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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P01NS33718/NS/NINDS NIH HHS; P20 MH57180/MH/NIMH NIH HHS; R01 DC007658/DC/NIDCD NIH HHS; R01 DC007658-04/DC/NIDCD NIH HHS |
| Comments/Corrections | |
Erratum In:
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Brain Lang. 2011 May;117(2):100 Note: Naoum, Ansam [corrected to Groshong, Ansam] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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