Document Detail

Longitudinal bone loss in postmenopausal women with primary biliary cirrhosis and well-preserved liver function.
MedLine Citation:
PMID:  12472915     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES/DESIGN: Increased rate of bone loss has been reported in women with primary biliary cirrhosis (PBC) and varying degree of liver dysfunction. Whether bone loss is increased in patients without liver dysfunction is unclear. The aim of this study was to estimate retrospectively the rate of bone loss in postmenopausal women with PBC and well-preserved liver function.
SUBJECTS/INTERVENTIONS: Forty-three women with PBC, and classified as Child-Pugh class A, were included. Bone mineral density (BMD) was measured by dual energy X-ray absorptiometry at the lumbar spine and the femoral neck.
RESULTS: Median time between measurements of BMD was 26 months (range, 12-48 months). Twenty women were not receiving any bone protective treatment, i.e. hormone replacement therapy (HRT), bisphosphonates or vitamin D/calcium supplementation, whilst 23 women received such treatment. Mean annual bone loss in the former group was 0.38 +/- 2.56% and 0.42 +/- 2.29% at the lumbar spine and the femoral neck, respectively. Women receiving treatment, however, increased their BMD by 1.92 +/- 3.76% and 0.15 +/- 2.75% at the lumbar spine and the femoral neck, respectively. At the lumbar spine the difference with regard to changes in BMD between untreated and treated women was statistically significant (P = 0.02). Women who received HRT (n = 11) increased their BMD at the lumbar spine by 2.95 +/- 3.91%, P = 0.03 when compared with untreated women.
CONCLUSION: Bone loss in postmenopausal women with PBC and well-preserved liver function is not increased above normal. Treatment with bone protective treatment, mainly HRT, improves BMD at the lumbar spine.
S Ormarsdóttir; O Ljunggren; H Mallmin; R Olsson; H Prytz; L Lööf
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of internal medicine     Volume:  252     ISSN:  0954-6820     ISO Abbreviation:  J. Intern. Med.     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2002-12-10     Completed Date:  2003-02-20     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  8904841     Medline TA:  J Intern Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  537-41     Citation Subset:  IM    
Institution for Medical Sciences and Surgical Sciences, University Hospital, Uppsala, Sweden.
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MeSH Terms
Bone Density
Femur Neck
Hormone Replacement Therapy / methods
Liver Cirrhosis, Biliary / complications*,  physiopathology
Lumbar Vertebrae
Middle Aged
Osteoporosis, Postmenopausal / etiology*,  physiopathology
Retrospective Studies

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