Document Detail

Longitudinal assessment of hypercapnic ventilatory drive after tracheotomy in a patient with the Prader-Willi syndrome.
MedLine Citation:
PMID:  8836675     Owner:  NLM     Status:  MEDLINE    
The clinical course and changes in hypercapnic ventilatory drive over time were serially assessed before and after tracheostomy placement in a 14 year old, morbidly obese female patient with Prader-Willi syndrome, severe obstructive sleep apnoea, and obesity-hypoventilation syndrome. A tracheostomy became necessary after supplemental oxygen and continuous positive airway pressure (CPAP) had failed to improve the severity of nocturnal hypoventilation. Continued improvement in the slope to rebreathing hyperoxic hypercapnia occurred from 2-10 weeks after tracheotomy in conjunction with night-time bilevel pressure ventilation, and remained unchanged thereafter. In contrast, increases in mean resting minute ventilation at an end-tidal carbon dioxide tension (PET,CO2) of 8 kPa (60 mmHg) were documented even after 30 weeks. This case study illustrates the time-frame of dynamic ventilatory changes occurring after removal of upper airway resistance and normalization of nocturnal alveolar ventilation.
D Gozal; J E Torres; A A Menendez
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The European respiratory journal     Volume:  9     ISSN:  0903-1936     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  1996 Jul 
Date Detail:
Created Date:  1996-12-16     Completed Date:  1996-12-16     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  1565-8     Citation Subset:  IM    
Dept of Pediatrics, Tulane University School of Medicine, New Orleans, LA 70112, USA.
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MeSH Terms
Follow-Up Studies
Hypercapnia / physiopathology
Prader-Willi Syndrome / complications*,  physiopathology
Pulmonary Ventilation / physiology
Respiration, Artificial
Sleep Apnea Syndromes / etiology*,  surgery,  therapy*
Time Factors
Grant Support

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