| Longitudinal assessment of human immunodeficiency virus type 1 (HIV-1)-specific gamma interferon responses during the first year of life in HIV-1-infected infants. | |
| | |
MedLine Citation:
|
PMID: 15956557 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Human immunodeficiency virus type 1 (HIV-1) infection results in different patterns of viral replication in pediatric compared to adult populations. The role of early HIV-1-specific responses in viral control has not been well defined, because most studies of HIV-1-infected infants have been retrospective or cross-sectional. We evaluated the association between HIV-1-specific gamma interferon (IFN-gamma) release from the cells of infants of 1 to 3 months of age and peak viral loads and mortality in the first year of life among 61 Kenyan HIV-1-infected infants. At 1 month, responses were detected in 7/12 (58%) and 6/21 (29%) of infants infected in utero and peripartum, respectively (P = 0.09), and in approximately 50% of infants thereafter. Peaks of HIV-specific spot-forming units (SFU) increased significantly with age in all infants, from 251/10(6) peripheral blood mononuclear cells (PBMC) at 1 month of age to 501/10(6) PBMC at 12 months of age (P = 0.03), although when limited to infants who survived to 1 year, the increase in peak HIV-specific SFU was no longer significant (P = 0.18). Over the first year of life, infants with IFN-gamma responses at 1 month had peak plasma viral loads, rates of decline of viral load, and mortality risk similar to those of infants who lacked responses at 1 month. The strength and breadth of IFN-gamma responses at 1 month were not significantly associated with viral containment or mortality. These results suggest that, in contrast to HIV-1-infected adults, in whom strong cytotoxic T lymphocyte responses in primary infection are associated with reductions in viremia, HIV-1-infected neonates generate HIV-1-specific CD8+-T-cell responses early in life that are not clearly associated with improved clinical outcomes. |
| | |
Authors:
|
Barbara L Lohman; Jennifer A Slyker; Barbra A Richardson; Carey Farquhar; Jenniffer M Mabuka; Christopher Crudder; Tao Dong; Elizabeth Obimbo; Dorothy Mbori-Ngacha; Julie Overbaugh; Sarah Rowland-Jones; Grace John-Stewart |
Related Documents
:
|
10583887 - Monitoring the clearance of fetal rhd-positive red cells in fmh following rhd immunoglo... 22942597 - Congenital nasopharyngeal teratoma with a cleft palate: case report and a 7 year follo... 9472507 - Review of uptake of interventions to reduce mother to child transmission of hiv by wome... 19825137 - Outcome of different nevirapine administration strategies in preventin g mother-to-chil... 12188237 - Evaluation of fiberglass versus plaster of paris for immobilization of fractures of the... 12626827 - Survival and morbidity in extremely low birth weight (elbw) infants. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Journal of virology Volume: 79 ISSN: 0022-538X ISO Abbreviation: J. Virol. Publication Date: 2005 Jul |
Date Detail:
|
Created Date: 2005-06-15 Completed Date: 2005-08-19 Revised Date: 2012-04-30 |
Medline Journal Info:
|
Nlm Unique ID: 0113724 Medline TA: J Virol Country: United States |
Other Details:
|
Languages: eng Pagination: 8121-30 Citation Subset: IM |
Affiliation:
|
Department of Paediatrics, University of Nairobi, Kenya. bllohman@iconnect.co.ke |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Amino Acid Sequence Antiviral Agents / therapeutic use CD8-Positive T-Lymphocytes / immunology Female HIV Infections / drug therapy*, mortality HIV-1 / drug effects* Humans Infant Infectious Disease Transmission, Vertical Interferon-gamma / therapeutic use* Kenya Peptide Fragments / chemistry Pregnancy Pregnancy Complications, Infectious / virology Viral Load |
| Grant Support | |
ID/Acronym/Agency:
|
D43 TW00007/TW/FIC NIH HHS; HD23412-14/HD/NICHD NIH HHS; K01 AI087369/AI/NIAID NIH HHS; TW06080/TW/FIC NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Antiviral Agents; 0/Peptide Fragments; 82115-62-6/Interferon-gamma |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Novel nuclear export signal-interacting protein, NESI, critical for the assembly of hepatitis delta ...
Next Document: Effect of CD8+ lymphocyte depletion on virus containment after simian immunodeficiency virus SIVmac2...