Document Detail


Longitudinal assessment of human immunodeficiency virus type 1 (HIV-1)-specific gamma interferon responses during the first year of life in HIV-1-infected infants.
MedLine Citation:
PMID:  15956557     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Human immunodeficiency virus type 1 (HIV-1) infection results in different patterns of viral replication in pediatric compared to adult populations. The role of early HIV-1-specific responses in viral control has not been well defined, because most studies of HIV-1-infected infants have been retrospective or cross-sectional. We evaluated the association between HIV-1-specific gamma interferon (IFN-gamma) release from the cells of infants of 1 to 3 months of age and peak viral loads and mortality in the first year of life among 61 Kenyan HIV-1-infected infants. At 1 month, responses were detected in 7/12 (58%) and 6/21 (29%) of infants infected in utero and peripartum, respectively (P = 0.09), and in approximately 50% of infants thereafter. Peaks of HIV-specific spot-forming units (SFU) increased significantly with age in all infants, from 251/10(6) peripheral blood mononuclear cells (PBMC) at 1 month of age to 501/10(6) PBMC at 12 months of age (P = 0.03), although when limited to infants who survived to 1 year, the increase in peak HIV-specific SFU was no longer significant (P = 0.18). Over the first year of life, infants with IFN-gamma responses at 1 month had peak plasma viral loads, rates of decline of viral load, and mortality risk similar to those of infants who lacked responses at 1 month. The strength and breadth of IFN-gamma responses at 1 month were not significantly associated with viral containment or mortality. These results suggest that, in contrast to HIV-1-infected adults, in whom strong cytotoxic T lymphocyte responses in primary infection are associated with reductions in viremia, HIV-1-infected neonates generate HIV-1-specific CD8+-T-cell responses early in life that are not clearly associated with improved clinical outcomes.
Authors:
Barbara L Lohman; Jennifer A Slyker; Barbra A Richardson; Carey Farquhar; Jenniffer M Mabuka; Christopher Crudder; Tao Dong; Elizabeth Obimbo; Dorothy Mbori-Ngacha; Julie Overbaugh; Sarah Rowland-Jones; Grace John-Stewart
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of virology     Volume:  79     ISSN:  0022-538X     ISO Abbreviation:  J. Virol.     Publication Date:  2005 Jul 
Date Detail:
Created Date:  2005-06-15     Completed Date:  2005-08-19     Revised Date:  2013-06-09    
Medline Journal Info:
Nlm Unique ID:  0113724     Medline TA:  J Virol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  8121-30     Citation Subset:  IM    
Affiliation:
Department of Paediatrics, University of Nairobi, Kenya. bllohman@iconnect.co.ke
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Antiviral Agents / therapeutic use
CD8-Positive T-Lymphocytes / immunology
Female
HIV Infections / drug therapy*,  mortality
HIV-1 / drug effects*
Humans
Infant
Infectious Disease Transmission, Vertical
Interferon-gamma / therapeutic use*
Kenya
Peptide Fragments / chemistry
Pregnancy
Pregnancy Complications, Infectious / virology
Viral Load
Grant Support
ID/Acronym/Agency:
D43 TW00007/TW/FIC NIH HHS; HD23412-14/HD/NICHD NIH HHS; K01 AI087369/AI/NIAID NIH HHS; TW06080/TW/FIC NIH HHS
Chemical
Reg. No./Substance:
0/Antiviral Agents; 0/Peptide Fragments; 82115-62-6/Interferon-gamma
Comments/Corrections

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