Document Detail

Longitudinal assessment of heart rate variability in very low birth weight infants during their NICU stay.
MedLine Citation:
PMID:  16978804     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Maturation of the autonomic nervous system has not been studied in high-risk very low birth weight (VLBW) infants in the first few weeks of life. AIM: To characterize developmental changes in autonomic nervous system activity of high-risk VLBW infants from 23 to 38 weeks post-menstrual age by measuring heart rate variability (HRV). STUDY DESIGN AND SUBJECTS: In this prospective cohort study 38 infants admitted to Children's Memorial Hermann Hospital NICU were longitudinally followed weekly or biweekly. Heart period data were recorded while infants were resting in active sleep. OUTCOME MEASURES: Growth of spectral power of HRV in low-frequency (0.05-0.25 Hz) and high-frequency (0.25-1.00 Hz) bands was modeled with linear mixed-effects models. The high-frequency power provides a measure of respiratory sinus arrhythmia (RSA). RESULTS: Low-frequency power increases with post-menstrual age, and intubated infants have lower HRV. The increase in low-frequency power is faster (0.50+/-0.12 dB/week) than the increase in RSA (0.17+/-0.09 dB/week). CONCLUSION: This longitudinal data exhibits developmental maturation of the RSA and of the low-frequency power of HRV in high-risk VLBW infants.
Asif Z Khattak; Nikhil S Padhye; Amber L Williams; Robert E Lasky; Fernando R Moya; M Terese Verklan
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural     Date:  2006-09-14
Journal Detail:
Title:  Early human development     Volume:  83     ISSN:  0378-3782     ISO Abbreviation:  Early Hum. Dev.     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-04-27     Completed Date:  2007-12-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7708381     Medline TA:  Early Hum Dev     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  361-6     Citation Subset:  IM    
The University of Texas Medical School at Houston, Department of Pediatrics, 6431 Fannin Street, Houston, TX 77339, USA.
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MeSH Terms
Age Factors
Autonomic Nervous System / growth & development*
Heart Rate / physiology*
Infant, Newborn
Infant, Very Low Birth Weight / physiology*
Intensive Care Units, Neonatal
Longitudinal Studies
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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