Document Detail


Longitudinal assessment of glycosylated blood protein concentrations in normal pregnancy and gestational diabetes.
MedLine Citation:
PMID:  3698777     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Longitudinal changes in glycosylated hemoglobin concentration (GlyHb) and glycosylated serum protein concentration (GSP) in both normal pregnancy and pregnancy complicated by gestational diabetes were determined using affinity chromatography, a method in which nonenzymatically glycosylated proteins are specifically measured. At 7-10 wk gestation, GlyHb in women who developed diabetes (N = 21) was higher than GlyHb in normal women (N = 49) (6.7 +/- 0.2% versus 5.7 +/- 0.2%, respectively, P less than 0.001) and remained elevated throughout gestation. In normal pregnancy, GlyHb decreased to a nadir at 23-26 wk and returned to baseline concentration by 31-34 wk. In gestational diabetes, there was an initial increase in GlyHb to 7.1 +/- 0.5% at 11-14 wk followed by a steady decrease. At 7-10 wk, GSP in women who developed diabetes was not elevated compared with normal concentration, although at 11-14 wk there was significant difference between the two groups (P less than 0.02). In normal women, GSP remained constant throughout gestation. In gestational diabetes, GSP decreased to early pregnancy values (P less than 0.02). Glycosylated blood proteins were elevated in early gestation in women who developed gestational diabetes and may have predictive value in identifying women who will develop diabetes in pregnancy.
Authors:
M A Morris; A S Grandis; J C Litton
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Diabetes care     Volume:  9     ISSN:  0149-5992     ISO Abbreviation:  Diabetes Care     Publication Date:    1986 Mar-Apr
Date Detail:
Created Date:  1986-06-10     Completed Date:  1986-06-10     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7805975     Medline TA:  Diabetes Care     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  107-10     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Blood Proteins*
Chromatography, Affinity
Female
Glycoproteins*
Hemoglobin A, Glycosylated / metabolism*
Humans
Longitudinal Studies
Pregnancy*
Pregnancy in Diabetics / blood*
Grant Support
ID/Acronym/Agency:
AM26996/AM/NIADDK NIH HHS
Chemical
Reg. No./Substance:
0/Blood Proteins; 0/Glycoproteins; 0/Hemoglobin A, Glycosylated; 0/glycosylated serum protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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