Document Detail


Longitudinal assessment of erythrocyte fatty acid composition throughout pregnancy and post partum.
MedLine Citation:
PMID:  17406928     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Transfer of fatty acids from mother to fetus during pregnancy is a requirement for optimal fetal growth. We report a longitudinal study of full maternal erythrocyte fatty acid profile assessed at each trimester of pregnancy [mean 12.5 (range 8-14), 26.1 (24-28) and 35.5 (33-38) weeks' gestation] and in the post partum period [18.1 (12-26) weeks]. The study recruited healthy women (n=47) from routine antenatal clinics at the Princess Royal Maternity Unit, Glasgow, Scotland. There were increases in 16:1n7 (22%, p=0.0005), 24:1n9 (13%, p=0.0032), 22:5n6 (25%, p=0.0003), 18:3n3 (41%, p=0.0007) and 22:6n3 (20%, p=0.0005) concentrations during pregnancy. The greatest increases took place between gestations at sampling of 12.5 and 26.1 weeks. The change in 16:1n7 concentration between gestations at sampling of 12.5 and 35.3 weeks was negatively associated with maternal booking body mass index (r=-0.40, p=0.006). The change in 22:6n3 concentration was correlated with the change in 24:1n9 (r=0.70, p<0.001). In samples taken four months post partum, 14:0 concentration was lower (29%, p=0.0002) and 24:0 concentration (15%, p=0.0009) and n6/n3 ratio (11%, p=0.0019) were higher than at a gestation at sampling of 12.5 weeks. In conclusion, several fatty acids are specifically mobilised during pregnancy. The correlation between maternal 22:6n3 and 24:1n9 suggests that mobilisation of these fatty acids may be coordinated. The inverse relationship between 16:1n7 and maternal central obesity warrants further investigation.
Authors:
Frances Stewart; Vanessa A Rodie; Jane E Ramsay; Ian A Greer; Dilys J Freeman; Barbara J Meyer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-03-27
Journal Detail:
Title:  Lipids     Volume:  42     ISSN:  0024-4201     ISO Abbreviation:  Lipids     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-04-04     Completed Date:  2007-09-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0060450     Medline TA:  Lipids     Country:  United States    
Other Details:
Languages:  eng     Pagination:  335-44     Citation Subset:  IM    
Affiliation:
Division of Developmental Medicine, University of Glasgow, Royal Infirmary, Glasgow, G31 2ER, UK.
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MeSH Terms
Descriptor/Qualifier:
Adult
Body Mass Index
Erythrocytes / metabolism*
Fatty Acids / blood*
Female
Humans
Postpartum Period / blood*
Pregnancy
Pregnancy Trimesters / blood*
Time Factors
Chemical
Reg. No./Substance:
0/Fatty Acids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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