Document Detail


Longitudinal assessment of chlorpyrifos exposure and effect biomarkers in adolescent Egyptian agricultural workers.
MedLine Citation:
PMID:  23321857     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Chlorpyrifos (CPF) is applied seasonally in Egypt by adolescent agricultural workers and the extent of occupational exposure and the potential for environmental CPF exposure in this population is poorly understood. Adolescent pesticide applicators (n=57; 12-21 years of age) and age-matched non-applicators (n=38) from the same villages were followed for 10 months in 2010, spanning pre-application through post-application. Eight urine and five blood samples were collected from participants within this time period. Blood acetylcholinesterase and butyrylcholinesterase (BChE; exposure/effect biomarker) and urine 3,5,6-trichloro-2-pyridinol (TCPy; exposure biomarker) were used to assess occupational CPF exposures in pesticide applicators and environmental exposures in non-applicators. Applicators demonstrated significantly higher TCPy concentration and BChE depression than non-applicators throughout CPF application. This difference persisted for 4-7 weeks after the cessation of agricultural spraying. However, both groups exhibited significantly elevated TCPy and depressed BChE, compared with their respective baseline. The peak TCPy levels during the spray season (95% confidence interval (CI)) for non-applicators and applicators reached 16.8 (9.87-28.5) and 137 (57.4-329) ug/g creatinine, respectively. BChE levels (95% CIs) during the spray were as follows: 1.47 (1.28-1.68) for non-applicators and 0.47 (0.24-0.94) U/ml for applicators. The longitudinal assessment of CPF biomarkers provided robust measures of exposure and effect throughout CPF application in adolescents and revealed significant exposures in both applicators and non-applicators. Biomarker data in the non-applicators, which mirrored that of the applicators, indicated that non-applicators received environmental CPF exposures. This suggests that similar exposures may occur in other residents of this region during periods of pesticide application.
Authors:
Alice L Crane; Gaafar Abdel Rasoul; Ahmed A Ismail; Olfat Hendy; Matthew R Bonner; Michael R Lasarev; Manal Al-Batanony; Steven T Singleton; Khalid Khan; James R Olson; Diane S Rohlman
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2013-01-16
Journal Detail:
Title:  Journal of exposure science & environmental epidemiology     Volume:  23     ISSN:  1559-064X     ISO Abbreviation:  J Expo Sci Environ Epidemiol     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-06-19     Completed Date:  2013-12-09     Revised Date:  2014-08-20    
Medline Journal Info:
Nlm Unique ID:  101262796     Medline TA:  J Expo Sci Environ Epidemiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  356-62     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acetylcholinesterase / blood
Adolescent
Agriculture / statistics & numerical data*
Biological Markers / blood,  urine
Butyrylcholinesterase / blood
Child
Chlorpyrifos / blood*,  urine
Egypt / epidemiology
Humans
Insecticides / blood*,  urine
Longitudinal Studies
Male
Occupational Exposure / analysis*
Pyridones / urine
Seasons
Young Adult
Grant Support
ID/Acronym/Agency:
ES017223/ES/NIEHS NIH HHS; F30 ES020655/ES/NIEHS NIH HHS; F30 ES020655/ES/NIEHS NIH HHS; P30 ES005605/ES/NIEHS NIH HHS; R01 ES022163/ES/NIEHS NIH HHS; R21 ES017223/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Insecticides; 0/Pyridones; 6515-38-4/3,5,6-trichloro-2-pyridinol; EC 3.1.1.-/Butyrylcholinesterase; EC 3.1.1.7/Acetylcholinesterase; JCS58I644W/Chlorpyrifos
Comments/Corrections

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