Document Detail

Longitudinal assessment of MAO-, COMT-, and DBH- activity in patients with bipolar depression.
MedLine Citation:
PMID:  6979526     Owner:  NLM     Status:  MEDLINE    
This study was carried out to determine whether the activity of regulatory enzymes for biogenic amines are state variables or trait variables for bipolar depression. The activity of MAO, COMT, and DBH in platelets, RBC and serum, respectively, was measured repeatedly in patients with bipolar depression and in matched control subjects. An increase in MAO activity was observed in patients compared to controls, while MAO activity was unrelated to the patient's psychopathological state. COMT activity was higher in female patients than in female controls and was lower in male patients than in male controls, but it failed to be related to the psychopathological state of patients. Relevant differences in serum DBH activity failed to occur either between patients and controls, or in patients during different states of their illness. The findings suggest that the activity of MAO and COMT are trait variables for bipolar depression, while DBH activity is neither a state variable nor a trait variable. it is discussed why only longitudinal studies in contrast to conventional cross-sectional assessments allow a distinction between state and trait variables.
E Fähndrich; B Müller-Oerlinghausen; H Coper
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International pharmacopsychiatry     Volume:  17     ISSN:  0020-8272     ISO Abbreviation:  Int Pharmacopsychiatry     Publication Date:  1982  
Date Detail:
Created Date:  1982-08-26     Completed Date:  1982-08-26     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0135645     Medline TA:  Int Pharmacopsychiatry     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  8-17     Citation Subset:  IM    
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MeSH Terms
Bipolar Disorder / enzymology*,  psychology
Blood Platelets / enzymology
Catechol O-Methyltransferase / blood*
Cross-Sectional Studies
Dopamine beta-Hydroxylase / blood*
Erythrocytes / enzymology
Longitudinal Studies
Middle Aged
Monoamine Oxidase / blood*
Sex Factors
Reg. No./Substance:
EC beta-Hydroxylase; EC Oxidase; EC O-Methyltransferase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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