Document Detail

Longitudinal analysis of mammary cancer multiplicity in chemoprevention studies.
MedLine Citation:
PMID:  10953286     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The effect of chemopreventive agents on cancer multiplicity is of primary interest in animal studies. The nature of data collected from chemoprevention studies may be analyzed by a longitudinal analysis of repeatedly measured cancer multiplicity data. METHODS: We determined the number of mammary cancers over the entire follow-up period for varying doses of two chemopreventive agents. Longitudinal analyses were performed to model the number of cancers over different time intervals. RESULTS: There was a significant increase in the number of cancers between six to seven weeks post-carcinogen administration in the control group. Varying patterns of cancer development were observed at different doses of chemopreventive agents including a delay in onset of tumor growth compared to the control group. CONCLUSION: Longitudinal data analysis complements traditional analyses by providing detailed information regarding the effect of chemopreventive agents on the pattern of tumor development throughout the follow-up period. Importantly, some chemopreventive agents may delay time to appearance of mammary cancers without causing a significant difference in cancer multiplicity.
H L Weiss; C Rodríguez-Burford; C J Grubbs; W E Grizzle
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anticancer research     Volume:  20     ISSN:  0250-7005     ISO Abbreviation:  Anticancer Res.     Publication Date:    2000 Jul-Aug
Date Detail:
Created Date:  2000-08-31     Completed Date:  2000-08-31     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8102988     Medline TA:  Anticancer Res     Country:  GREECE    
Other Details:
Languages:  eng     Pagination:  2281-7     Citation Subset:  IM    
Biostatistics Unit, University of Alabama at Birmingham 35294, USA.
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MeSH Terms
Anticarcinogenic Agents / pharmacology*
Mammary Neoplasms, Experimental / pathology,  prevention & control*
Rats, Sprague-Dawley
Time Factors
Triazoles / pharmacology
Vitamin A / analogs & derivatives,  pharmacology
Reg. No./Substance:
0/Anticarcinogenic Agents; 0/Triazoles; 11103-57-4/Vitamin A; 118949-22-7/vorozole; 1224-78-8/anhydrovitamin A; 127-47-9/retinol acetate

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