Document Detail


Longitudinal analysis of feline leukemia virus-specific cytotoxic T lymphocytes: correlation with recovery from infection.
MedLine Citation:
PMID:  11836409     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Feline leukemia virus (FeLV) is a common naturally occurring gammaretrovirus of domestic cats that is associated with degenerative diseases of the hematopoietic system, immunodeficiency, and neoplasia. Although the majority of cats exposed to FeLV develop a transient infection and recover, a proportion of cats become persistently viremic and many subsequently develop fatal diseases. To define the dominant host immune effector mechanisms responsible for the outcome of infection, we studied the longitudinal changes in FeLV-specific cytotoxic T lymphocytes (CTLs) in a group of naïve cats following oronasal exposure to FeLV. Using (51)Cr release assays to measure ex vivo virus-specific cytotoxicity, the emerging virus-specific CTL response was correlated with modulations in viral burden as assessed by detection of infectious virus, FeLV p27 capsid antigen, and proviral DNA in the blood. High levels of circulating FeLV-specific effector CTLs appeared before virus neutralizing antibodies in cats that recovered from exposure to FeLV. In contrast, persistent viremia was associated with a silencing of virus-specific humoral and cell-mediated host immune effector mechanisms. A single transfer of between 2 x 10(7) and 1 x 10(8) autologous, antigen-activated lymphoblasts was associated with a downmodulation in viral burden in vivo. The results suggest an important role for FeLV-specific CTLs in retroviral immunity and demonstrate the potential to modulate disease outcome by the adoptive transfer of antigen-specific T cells in vivo.
Authors:
J Norman Flynn; Stephen P Dunham; Vivien Watson; Oswald Jarrett
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of virology     Volume:  76     ISSN:  0022-538X     ISO Abbreviation:  J. Virol.     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-02-11     Completed Date:  2002-03-15     Revised Date:  2013-04-18    
Medline Journal Info:
Nlm Unique ID:  0113724     Medline TA:  J Virol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2306-15     Citation Subset:  IM    
Affiliation:
Retrovirus Research Laboratory, Department of Veterinary Pathology, University of Glasgow, Bearsden, Glasgow G61 1QH, Scotland. n.flynn@vet.gla.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Adoptive Transfer
Animals
Antibodies, Viral / blood,  immunology
Cats
DNA, Viral / blood
Gene Products, gag / blood
Leukemia Virus, Feline / immunology*,  isolation & purification
Proviruses
Retroviridae Infections / immunology*,  virology
T-Lymphocytes, Cytotoxic / immunology*
Tumor Virus Infections / immunology*,  virology
Viremia / immunology*,  virology
Chemical
Reg. No./Substance:
0/Antibodies, Viral; 0/DNA, Viral; 0/Gene Products, gag; 0/p24 protein, Feline immunodeficiency virus
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