| Longitudinal analysis of bone mineral density in pre-menopausal female systemic lupus erythematosus patients: deleterious role of glucocorticoid therapy at the lumbar spine. | |
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MedLine Citation:
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PMID: 10817771 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate whether bone loss occurs over time in pre-menopausal systemic lupus erythematosus (SLE) patients. METHODS: We performed a longitudinal bone mineral density (BMD) analysis in a group of 35 pre-menopausal female SLE patients. Lumbar spine and hip (total and sub-regions) BMDs were measured twice 21 +/- 11 (mean +/- S.D.) months apart by dual-energy X-ray absorptiometry. RESULTS: In the whole cohort of SLE patients, significant bone loss was observed at the lumbar spine (-1.22%/yr) but not at the total hip. Further analyses indicated that lumbar spine bone loss (-2.12%/yr) occurred exclusively in the subgroup of patients who had taken a mean prednisolone daily dose >7.5 mg between the two BMD measurements. Moreover, bone loss was more important in patients who had previously received a cumulative prednisolone dose </=5 g by the time of their first BMD evaluation. CONCLUSIONS: These results, by demonstrating a loss of lumbar spine bone over time in pre-menopausal SLE patients given glucocorticoid (GC) therapy, strongly support the use of preventive treatment to minimize GC-induced osteoporosis in pre-menopausal female SLE patients given prednisolone daily doses >7.5 mg. |
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Authors:
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D Jardinet; C Lefèbvre; G Depresseux; M Lambert; J P Devogelaer; F A Houssiau |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Rheumatology (Oxford, England) Volume: 39 ISSN: 1462-0324 ISO Abbreviation: Rheumatology (Oxford) Publication Date: 2000 Apr |
Date Detail:
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Created Date: 2000-06-28 Completed Date: 2000-06-28 Revised Date: 2007-09-06 |
Medline Journal Info:
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Nlm Unique ID: 100883501 Medline TA: Rheumatology (Oxford) Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 389-92 Citation Subset: AIM; IM |
Affiliation:
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Rheumatology Department, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Bruxelles, Belgium. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Bone Density / drug effects* Female Humans Longitudinal Studies Lumbar Vertebrae / pathology Lupus Erythematosus, Systemic / complications, drug therapy* Prednisolone / adverse effects*, therapeutic use Premenopause* |
| Chemical | |
Reg. No./Substance:
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50-24-8/Prednisolone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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