Document Detail


Longitudinal whole-brain N-acetylaspartate concentration in healthy adults.
MedLine Citation:
PMID:  21511862     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND PURPOSE: Although NAA is often used as a marker of neural integrity and health in different neurologic disorders, the temporal behavior of WBNAA is not well characterized. Our goal therefore was to establish its normal variations in a cohort of healthy adults over typical clinical trial periods.
MATERIALS AND METHODS: Baseline amount of brain NAA, Q(NAA), was obtained with nonlocalizing proton MR spectroscopy from 9 subjects (7 women, 2 men; 31.2 ± 5.6 years old). Q(NAA) was converted into absolute millimole amount by using phantom-replacement. The WBNAA concentration was derived by dividing Q(NAA) with the brain parenchyma volume, V(B), segmented from MR imaging. Temporal variations were determined with 4 annual scans of each participant.
RESULTS: The distribution of WBNAA levels was not different among time points with respect to the mean, 12.1 ± 1.5 mmol/L (P > .6), nor was its intrasubject change (coefficient of variation = 8.6%) significant between any 2 scans (P > .5). There was a small (0.2 mL) but significant (P = .05) annual V(B) decline.
CONCLUSIONS: WBNAA is stable over a 3-year period in healthy adults. It qualifies therefore as a biomarker for global neuronal loss and dysfunction in diffuse neurologic disorders that may be well worth considering as a secondary outcome measure candidate for clinical trials.
Authors:
D J Rigotti; I I Kirov; B Djavadi; N Perry; J S Babb; O Gonen
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-04-21
Journal Detail:
Title:  AJNR. American journal of neuroradiology     Volume:  32     ISSN:  1936-959X     ISO Abbreviation:  AJNR Am J Neuroradiol     Publication Date:    2011 Jun-Jul
Date Detail:
Created Date:  2011-06-14     Completed Date:  2012-03-01     Revised Date:  2014-09-20    
Medline Journal Info:
Nlm Unique ID:  8003708     Medline TA:  AJNR Am J Neuroradiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1011-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aspartic Acid / analogs & derivatives*,  analysis
Brain Chemistry*
Female
Humans
Longitudinal Studies
Magnetic Resonance Spectroscopy / methods*
Male
Reference Values
Reproducibility of Results
Sensitivity and Specificity
Young Adult
Grant Support
ID/Acronym/Agency:
EB01015/EB/NIBIB NIH HHS; NS050520/NS/NINDS NIH HHS; R01 EB001015/EB/NIBIB NIH HHS; R01 EB001015-16/EB/NIBIB NIH HHS; R01 NS050520/NS/NINDS NIH HHS; R01 NS050520-05/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
30KYC7MIAI/Aspartic Acid; 997-55-7/N-acetylaspartate
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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