| A longitudinal study of serum lipoproteins in relation to endogenous reproductive hormones during the menstrual cycle: findings from the BioCycle study. | |
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MedLine Citation:
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PMID: 20534764 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CONTEXT: Exogenous estrogens have been shown to affect the lipid profile, leading to the hypothesis that endogenous estrogens may have similar effects. OBJECTIVE: The objective of the study was to evaluate the association between endogenous estrogen and serum lipoproteins across the menstrual cycle. DESIGN: This was a prospective cohort study. SETTING: The study was conducted at the University at Buffalo, 2005-2007. PARTICIPANTS: Participants included 259 healthy, regularly menstruating women aged 18-44 yr. MAIN OUTCOME MEASURES: Serum levels of total, high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol, and triglycerides measured up to eight times per cycle for up to two cycles were measured. RESULTS: Total and LDL cholesterol were lower during the luteal phase as compared with the follicular phase (P < 0.001), and HDL levels were highest around ovulation (P < 0.001). More women were classified above the desirable range (LDL > or =130 mg/dl or total cholesterol > or =200 mg/dl) when measured during the follicular phase. Estradiol was positively associated with HDL in acute effects models [beta = 0.019, 95% confidence interval (CI) 0.015, 0.022] and inversely associated with total (beta = -0.017, 95% CI -0.020, -0.014) and LDL cholesterol (beta = -0.023, 95% CI -0.027, -0.018) and triglycerides (beta = -0.041, 95% CI -0.054, -0.029) in persistent effects models. CONCLUSIONS: Endogenous estrogen, like exogenous estrogen, appears to have beneficial effects on the lipid profile. Because lipoprotein cholesterol levels vary across the menstrual cycle, cyclic variations in lipoprotein levels may need to be considered in the design and interpretation of studies in reproductive-age women and in the clinical management of women's cholesterol. |
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Authors:
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Sunni L Mumford; Enrique F Schisterman; Anna Maria Siega-Riz; Richard W Browne; Audrey J Gaskins; Maurizio Trevisan; Anne Z Steiner; Julie L Daniels; Cuilin Zhang; Neil J Perkins; Jean Wactawski-Wende |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Intramural Date: 2010-06-09 |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: 95 ISSN: 1945-7197 ISO Abbreviation: J. Clin. Endocrinol. Metab. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-08 Completed Date: 2010-09-28 Revised Date: 2011-09-13 |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: United States |
Other Details:
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Languages: eng Pagination: E80-5 Citation Subset: AIM; IM |
Affiliation:
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Epidemiology Branch, Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20852, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Cohort Studies Female Gonadal Steroid Hormones / blood* Humans Lipoproteins / blood* Longitudinal Studies Menstrual Cycle / blood* Triglycerides / blood Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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R24 HD050924-07/HD/NICHD NIH HHS; Z01 HD008762-05/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Gonadal Steroid Hormones; 0/Lipoproteins; 0/Triglycerides |
| Comments/Corrections | |
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