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A Longitudinal Study Evaluating the Effect of Exacerbations on Physical Activity in Patients with Chronic Obstructive Pulmonary Disease.
MedLine Citation:
PMID:  24053416     Owner:  NLM     Status:  Publisher    
Background: Physical inactivity is common in stable COPD and independently predicts poor outcomes. Longitudinal assessments of physical activity in outpatients with COPD, covering periods of stability and exacerbations, have not been evaluated previously. Methods: Patients with clinically-stable COPD and a history of 2 or more clinical exacerbations in the preceding 12 months were recruited. Physical activity was measured using a tri-axial accelerometer worn continuously on the non-dominant wrist. Mean minutes per day of higher level physical activity was the primary outcome variable. Symptom-defined exacerbations were assessed using the 14-item Exacerbations of Chronic Pulmonary Disease Tool (EXACT) daily dairy. Clinically-reported exacerbations were also captured. Minutes per day of higher level physical activity during exacerbation and non-exacerbation days were compared using a mixed model analysis. Results: Seventeen patients were followed for 135 ± 18 days. Nine were male with a mean age of 63 ±12 years and mean FEV1 of 52 ± 20 %. Fifteen patients had 27 symptom (EXACT) defined exacerbations, including 9 that were also clinically-reported. Patients spent fewer minutes per day at a higher level physical activity during exacerbation days than non-exacerbation days: 131 ± 14 vs.157 ± 14 minutes, p<0.0001. The greatest reduction in physical activity was during the first week of the exacerbation; activity remained low for approximately 2 weeks after exacerbation resolution. Conclusions: Physical activity decreased significantly during exacerbations. Reduction in activity occurs early during an exacerbation and persists for about 2 weeks following symptomatic recovery.
Mohsin Ehsan; Rana Khan; Dorothy Wakefield; Asher Qureshi; Lindsey Murray; Richard Zuwallack; Nancy Kline Leidy
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-9-20
Journal Detail:
Title:  Annals of the American Thoracic Society     Volume:  -     ISSN:  2325-6621     ISO Abbreviation:  Ann Am Thorac Soc     Publication Date:  2013 Sep 
Date Detail:
Created Date:  2013-9-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101600811     Medline TA:  Ann Am Thorac Soc     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
University of Connecticut, Fellow Department of Pulmonary and Critical Care, Farmington, Connecticut, United States ;
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