| Longitudinal studies of Plasmodium falciparum malaria in pregnant women living in a rural Cameroonian village with high perennial transmission. | |
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MedLine Citation:
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PMID: 21036826 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A prospective longitudinal study of Plasmodium falciparum in pregnant women was conducted in the rural village of Ngali II, where malaria is hyperendemic and individuals receive ~0.7 infectious mosquito bites/person/day throughout the year. Pregnant women (N = 60; 19 primigravidae, 41 multigravidae) were enrolled early in pregnancy (median 14 wk) and were followed monthly, with 38 women followed through term (5.7 ± 1.1 prenatal visits and delivery). The total number of times primigravidae were slide-positive during pregnancy was higher than multigravidae (3.3 ± 1.1 versus 1.3 ± 1.3 times; P < 0.001), but no difference in the number of polymerase chain reaction-positive cases (4.6 ± 1.7 and 3.4 ± 1.7 times, P = 0.106) or total genotypes they harbored (8.9 ± 3.2 and 7.0 ± 2.9) was found. Only 7.9% women developed symptomatic infections. All primigravidae and 38% multigravidae were placental malaria-positive at delivery (P = 0.009). Genotyping showed that 77% of placental parasites were acquired ≥ 30 wks in pregnancy. These results help identify the extent of malaria-associated changes women experience during pregnancy. |
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Authors:
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Rose F G Leke; Jude D Bioga; James Zhou; Genevieve G Fouda; Robert J I Leke; Viviane Tchinda; Rosette Megnekou; Josephine Fogako; Grace Sama; Philomina Gwanmesia; Germaine Bomback; Charles Nama; Ababacar Diouf; Naveen Bobbili; Diane Wallace Taylor |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: The American journal of tropical medicine and hygiene Volume: 83 ISSN: 1476-1645 ISO Abbreviation: Am. J. Trop. Med. Hyg. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-01 Completed Date: 2010-11-30 Revised Date: 2011-11-07 |
Medline Journal Info:
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Nlm Unique ID: 0370507 Medline TA: Am J Trop Med Hyg Country: United States |
Other Details:
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Languages: eng Pagination: 996-1004 Citation Subset: AIM; IM |
Affiliation:
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Faculty of Medicine and Biomedical Research, The Biotechnology Center, University of Yaoundé 1, Yaoundé, Cameroon. roseleke@yahoo.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Animals Anopheles / physiology Cameroon / epidemiology Child Child, Preschool Female Humans Infant Infant, Newborn Longitudinal Studies Malaria, Falciparum / drug therapy, epidemiology*, prevention & control, transmission* Male Middle Aged Plasmodium falciparum / isolation & purification Polymerase Chain Reaction Population Dynamics Pregnancy Pregnancy Complications, Parasitic / drug therapy, epidemiology*, prevention & control Prevalence Rain Seasons Time Factors Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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UO1 AI43888/AI/NIAID NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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