| Longitudinal MRI atrophy biomarkers: relationship to conversion in the ADNI cohort. | |
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MedLine Citation:
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PMID: 20620664 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Atrophic changes in early Alzheimer's disease (AD) and amnestic mild cognitive impairment (MCI) have been proposed as biomarkers for detection and monitoring. We analyzed magnetic resonance imaging (MRI) atrophy rate from baseline to 1 year in 4 groups of participants from the Alzheimer's Disease Neuroimaging Initiative (ADNI): AD (n = 152), converters from MCI to probable AD (MCI-C, n = 60), stable MCI (MCI-S, n = 261), and healthy controls (HC, n = 200). Scans were analyzed using multiple methods, including voxel-based morphometry (VBM), regions of interest (ROIs), and automated parcellation, permitting comparison of annual percent change (APC) in neurodegeneration markers. Effect sizes and the sample required to detect 25% reduction in atrophy rates were calculated. The influence of APOE genotype on APC was also evaluated. AD patients and converters from MCI to probable AD demonstrated high atrophy APCs across regions compared with minimal change in healthy controls. Stable MCI subjects showed intermediate atrophy rates. APOE genotype was associated with APC in key regions. In sum, APC rates are influenced by APOE genotype, imminent MCI to AD conversion, and AD-related neurodegeneration. |
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Authors:
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Shannon L Risacher; Li Shen; John D West; Sungeun Kim; Brenna C McDonald; Laurel A Beckett; Danielle J Harvey; Clifford R Jack; Michael W Weiner; Andrew J Saykin; |
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Publication Detail:
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Type: Comparative Study; Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Neurobiology of aging Volume: 31 ISSN: 1558-1497 ISO Abbreviation: Neurobiol. Aging Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-12 Completed Date: 2011-03-29 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 8100437 Medline TA: Neurobiol Aging Country: United States |
Other Details:
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Languages: eng Pagination: 1401-18 Citation Subset: IM |
Copyright Information:
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2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University, School of Medicine, 950 W Walnut St., Indianapolis, IN 46202, United States. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Alzheimer Disease / genetics*, metabolism, pathology* Apolipoprotein E4 / genetics Atrophy Biological Markers / metabolism Cognition Disorders / genetics*, metabolism, pathology* Cohort Studies Disease Progression* Female Humans Longitudinal Studies Magnetic Resonance Imaging* / trends Male Prospective Studies |
| Grant Support | |
ID/Acronym/Agency:
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K01 AG030514/AG/NIA NIH HHS; P30 AG010129/AG/NIA NIH HHS; P30 AG010129-20/AG/NIA NIH HHS; P30 AG010133-18S1/AG/NIA NIH HHS; P30 AG10133-18S1/AG/NIA NIH HHS; R01 AG019771-08/AG/NIA NIH HHS; R01 AG19771/AG/NIA NIH HHS; R03 EB008674/EB/NIBIB NIH HHS; R03 EB008674-01/EB/NIBIB NIH HHS; RC2 AG036535/AG/NIA NIH HHS; U01 AG024904/AG/NIA NIH HHS; U01 AG024904-04/AG/NIA NIH HHS; U24 AG021886/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Apolipoprotein E4; 0/Biological Markers |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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