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Longitudinal Factor Analysis Reveals a Distinct Clustering of Cardiometabolic Improvements During Intensive, Short-Term Dietary and Exercise Intervention in Obese Children and Adolescents.
MedLine Citation:
PMID:  21936669     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Objective: The aim of this study was to investigate changes in cardiometabolic clustering characteristics in response to highly significant weight loss. Background: Pre-post analysis of a lifestyle intervention for the treatment of obesity and the assessment of interrelated metabolic changes were analyzed using principal component analysis (PCA). A total of n=75 clinically obese boys and girls [standardized body mass index (sBMI) 3.07±0.59] aged 8-18 years were assessed after lifestyle intervention (30±12 days). Results: There were favorable improvements in BMI waist circumference, fasting insulin, triglycerides (TGs), systolic blood pressure (SBP) and diastolic blood pressure (DBP) (all P<0.001). PCA was performed using a simple conceptual model of changes in six metabolic variables: Overall and central obesity (BMI and waist circumference), dyslipidemia [TG and high-density lipoprotein cholesterol (HDL-C)], insulin resistance [fasting insulin or homeostasis model assessment of insulin resistance (HOMA-IR)], and blood pressure [SBP or mean arterial pressure (MAP)]. PCA models consistently identified two factors underlying the changes in six cardiometabolic variables. These were labeled a "metabolic" factor, typically including waist circumference, fasting triglyceride, insulin, or HOMA-IR and HDL-C (negatively) and an "obesity/blood pressure" factor, typically loading waist, BMI, SBP or MAP, and occasionally fasting insulin/HOMA-IR). The metabolic and obesity/blood pressure factors explained 26.5%-28.4% and 30.4%-31.9%, of the variance in metabolic risk factors changes, respectively. Reductions in BMI, waist circumference, and HOMA-IR (or fasting insulin) were central underlying features of cardiometabolic changes. Conclusion: There were significant and favorable cardiometabolic risk factor changes to short-term weight-loss. A distinct clustering of cardiometabolic responses supports the etiological importance of both overall and central obesity and insulin resistance in the modification of cardiometabolic risk in obese youths.
Authors:
James P Hobkirk; Roderick F King; Paul Gately; Philip Pemberton; Alexander Smith; Julian H Barth; Sean Carroll
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-9-21
Journal Detail:
Title:  Metabolic syndrome and related disorders     Volume:  -     ISSN:  1557-8518     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-9-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101150318     Medline TA:  Metab Syndr Relat Disord     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1 Department of Academic Cardiology, Castle Hill Hospital , Hull, United Kingdom .
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