| Longitudinal evaluation of the effects of alendronate on MRI bone microarchitecture in postmenopausal osteopenic women. | |
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MedLine Citation:
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PMID: 21059422 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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INTRODUCTION: High-resolution magnetic resonance imaging (MRI) allows for non-invasive bone microarchitecture analysis. The goal of this study was to examine the potential of MRI-based trabecular bone structure parameters to monitor effects of alendronate in humans in vivo, and to compare the results to HR-pQCT and DXA measurements. MATERIALS AND METHODS: Postmenopausal osteopenic women were divided into alendronate treatment and control groups, and imaged at baseline, 12months, and 24months (n=52 at baseline) using 3T MRI, HR-pQCT, and DXA. Image acquisition sites included distal tibia (MRI and HR-pQCT), distal radius (MRI, DXA, and HR-pQCT), and the proximal femur (MRI and DXA). Two different regions of interest were evaluated. One contained the trabecular bone region within the entire MRI acquisition, and the second contained a subregion matched to the region contained in the HR-pQCT acquisition. The trabecular bone was segmented using two different methods; dual thresholding and BE-FCM. Trabecular bone structure parameters included bone volume fraction (BV/TV), number (Tb.N), spacing (Tb.Sp), and thickness (Tb.Th), along with seven geodesic topological analysis (GTA) parameters. Longitudinal changes and correlations to HR-pQCT and DXA measurements were evaluated. RESULTS: Apparent Tb.N and four GTA parameters showed treatment effects (p<0.05) in the distal tibia after 24months in the entire MRI region using BE-FCM, as well as Tb.N using dual thresholding. No treatment effects after 24 months were observed in the HR-pQCT or in MRI analysis for the HR-pQCT-matched regions. Apparent BV/TV and Tb.N from BE-FCM had significantly higher correlations to HR-pQCT values compared to those derived from thresholding. CONCLUSIONS: This study demonstrates the influence of computational methods and region of interest definitions on measurements of trabecular bone structure, and the feasibility of MRI-based quantification of longitudinal changes in bone microarchitecture due to bisphosphonate therapy. The results suggest that there may be a need to reevaluate the current standard HR-pQCT region definition for increased treatment sensitivity. |
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Authors:
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Jenny Folkesson; Janet Goldenstein; Julio Carballido-Gamio; Galateia Kazakia; Andrew J Burghardt; Ana Rodriguez; Roland Krug; Anne E de Papp; Thomas M Link; Sharmila Majumdar |
Publication Detail:
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Type: Journal Article Date: 2010-11-05 |
Journal Detail:
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Title: Bone Volume: 48 ISSN: 1873-2763 ISO Abbreviation: Bone Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8504048 Medline TA: Bone Country: United States |
Other Details:
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Languages: eng Pagination: 611-21 Citation Subset: IM |
Copyright Information:
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Published by Elsevier Inc. |
Affiliation:
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Musculoskeletal Quantitative Imaging Research Group (MQIR), Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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